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Crystal structure of PAV1-137: a protein from the virus PAV1 that infects Pyrococcus abyssi
- Source :
- Archaea, Archaea, Hindawi Publishing Corporation, 2013, 2013, pp.568053. ⟨10.1155/2013/568053⟩, Archaea-an International Microbiological Journal (1472-3646) (Hindawi Publishing Corporation), 2013, N. ID 568053, P. 1-5, Archaea, Hindawi Publishing Corporation, 2013, 2013, pp.568053. 〈10.1155/2013/568053〉, Archaea, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- Pyrococcus abyssivirus 1 (PAV1) was the first virus particle infecting a hyperthermophilic Euryarchaeota (Pyrococcus abyssistrain GE23) that has been isolated and characterized. It is lemon shaped and is decorated with a short fibered tail. PAV1 morphologically resembles the fusiform members of the family Fuselloviridae or the genusSalterprovirus. The 18 kb dsDNA genome of PAV1 contains 25 predicted genes, most of them of unknown function. To help assigning functions to these proteins, we have initiated structural studies of the PAV1 proteome. We determined the crystal structure of a putative protein of 137 residues (PAV1-137) at a resolution of 2.2 Å. The protein forms dimers both in solution and in the crystal. The fold of PAV1-137 is a four-α-helical bundle analogous to those found in some eukaryotic adhesion proteins such as focal adhesion kinase, suggesting that PAV1-137 is involved in protein-protein interactions.
- Subjects :
- Archaeal Viruses
Models, Molecular
Pyrococcus abyssi
Article Subject
Physiology
Protein Conformation
PREDICTION
GENOMES
Crystallography, X-Ray
Genome
Microbiology
Virus
Focal adhesion
[ SDE ] Environmental Sciences
03 medical and health sciences
Viral Proteins
Protein structure
DOMAIN
PARTICLES
Gene
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
0303 health sciences
biology
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]
030306 microbiology
ARCHAEAL VIRUS
biology.organism_classification
Molecular biology
QR1-502
3. Good health
Biochemistry
Proteome
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDE]Environmental Sciences
Euryarchaeota
Protein Multimerization
HIS1
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14723646 and 14723654
- Database :
- OpenAIRE
- Journal :
- Archaea, Archaea, Hindawi Publishing Corporation, 2013, 2013, pp.568053. ⟨10.1155/2013/568053⟩, Archaea-an International Microbiological Journal (1472-3646) (Hindawi Publishing Corporation), 2013, N. ID 568053, P. 1-5, Archaea, Hindawi Publishing Corporation, 2013, 2013, pp.568053. 〈10.1155/2013/568053〉, Archaea, Vol 2013 (2013)
- Accession number :
- edsair.doi.dedup.....a1122de8296009e7409bdc97d7cee802