Back to Search
Start Over
Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity
- Source :
- eLife, Vol 9 (2020), eLife, 9. eLife Sciences Publications, eLife, elife
- Publication Year :
- 2020
-
Abstract
- The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is established and maintained is poorly understood. Using the in vivo model system Caenorhabditis elegans, we found that the highly conserved UNC-119 protein provides a link between the membrane-associated Ankyrin (UNC-44) and the microtubule-associated CRMP (UNC-33). Together they form a periodic membrane-associated complex that anchors axonal and dendritic microtubule bundles to the cortex. This anchoring is critical to maintain microtubule organization by opposing kinesin-1 powered microtubule sliding. Disturbing this molecular complex alters neuronal polarity and causes strong developmental defects of the nervous system leading to severely paralyzed animals.
- Subjects :
- 0301 basic medicine
Nervous system
Ankyrin
Microtubules
Biochemistry
kinesin
0302 clinical medicine
Biology (General)
Cells, Cultured
Cytoskeleton
chemistry.chemical_classification
Cerebral Cortex
Neurons
Chemistry
General Neuroscience
Cell Polarity
General Medicine
CRMP
Microtubule sliding
Cell biology
Dendritic microtubule
medicine.anatomical_structure
C. elegans
Kinesin
Medicine
Locomotion
Research Article
neuron polarity
microtubule
Ankyrins
Polarity (physics)
QH301-705.5
Science
Neuroscience(all)
Nerve Tissue Proteins
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Microtubule
Immunology and Microbiology(all)
medicine
Animals
Nerve Growth Factors
Caenorhabditis elegans
Caenorhabditis elegans Proteins
General Immunology and Microbiology
Biochemistry, Genetics and Molecular Biology(all)
Cell Biology
030104 developmental biology
nervous system
Neuron
030217 neurology & neurosurgery
Neuroscience
Genetics and Molecular Biology(all)
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Database :
- OpenAIRE
- Journal :
- eLife, Vol 9 (2020), eLife, 9. eLife Sciences Publications, eLife, elife
- Accession number :
- edsair.doi.dedup.....a10f10ad956d9c7266dd14e1ddc530c3