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2,2'-Anhydro-1-(3',5'-di-O-acetyl-β-D-arabinofuranosyl)uracil, a cyclouridine nucleoside with a C4'-endo furanosyl conformation
- Source :
- Acta crystallographica. Section C, Crystal structure communications. 69(Pt 3)
- Publication Year :
- 2012
-
Abstract
- 2,2′-Anhydro-1-(3′,5′-di-O-acetyl-β-D-arabinofuranosyl)uracil, C13H14N2O7, was obtained by refluxing 2′,3′-O-(methoxymethylene)uridine in acetic anhydride. The structure exhibits a nearly perfect C4′-endo(4E) conformation. The best four-atom plane of the five-membered furanose ring is O—C—C—C, involving the C atoms of the fused five-membered oxazolidine ring, and the torsion angle is only −0.4 (2)°. The oxazolidine ring is essentially coplanar with the six-membered uracil ring [r.m.s. deviation = 0.012 (5) Å and dihedral angle = −3.2 (3)°]. The conformation at the exocyclic C—C bond isgauche–transwhich is stabilized by various C—H...π and C—O...π interactions.
- Subjects :
- Oxazolidine
Hydrogen bond
Stereochemistry
Arabinofuranosyluracil
Molecular Conformation
Uracil
Hydrogen Bonding
Nucleosides
General Medicine
Crystal structure
Dihedral angle
Ring (chemistry)
Crystallography, X-Ray
General Biochemistry, Genetics and Molecular Biology
Uridine
Acetic anhydride
chemistry.chemical_compound
chemistry
Subjects
Details
- ISSN :
- 16005759
- Volume :
- 69
- Issue :
- Pt 3
- Database :
- OpenAIRE
- Journal :
- Acta crystallographica. Section C, Crystal structure communications
- Accession number :
- edsair.doi.dedup.....a103d882385043177259444a26d0b977