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Measles, mumps and rubella vs diphtheria-tetanus-acellular-pertussis-inactivated-polio-Haemophilus influenzae type b as the most recent vaccine and risk of early 'childhood asthma'
- Source :
- Rieckmann, A, Hærskjold, A, Benn, C S, Aaby, P, Lange, T & Sørup, S 2019, ' Measles, mumps and rubella vs diphtheria-tetanus-acellular-pertussis-inactivated-polio-Haemophilus influenzae type b as the most recent vaccine and risk of early 'childhood asthma' ', International Journal of Epidemiology, vol. 48, no. 6, pp. 2026-2038 . https://doi.org/10.1093/ije/dyz062
- Publication Year :
- 2019
-
Abstract
- Background and objectiveLive vaccines may have beneficial non-specific effects. We tested whether the live measles, mumps and rubella (MMR) vaccine compared with the non-live diphtheria–tetanus–acellular-pertussis–inactivated-polio–Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine as the most recent vaccine was associated with less childhood asthma and fewer acute hospital contacts for childhood asthma among boys and girls.MethodsThis study is a nationwide register-based cohort study of 338 761 Danish children born between 1999 and 2006. We compared (i) the incidence of first-registered childhood asthma based on hospital contacts and drug prescriptions and (ii) the incidence of severe asthma defined as acute hospital contacts for childhood asthma between the ages of 15 and 48 months among children whose last received vaccine was three doses of DTaP-IPV-Hib and then MMR with children whose last received vaccine was three doses of DTaP-IPV-Hib.ResultsFor boys, following the recommended vaccine schedule of MMR after DTaP-IPV-Hib3 compared with DTaP-IPV-Hib3 as the last received vaccine, MMR was associated with 8.1 (95% confidence interval 3.9–12.3) fewer childhood asthma cases per 1000 boys, corresponding to 10% (5–15%) reduction in the cumulative incidence of childhood asthma. MMR, when given last, was also associated with 16.3 (95% confidence interval 12.7–20.0) fewer acute hospital admissions for childhood asthma per 1000 boys, corresponding to a 27% (22–31%) reduction in the cumulative incidence. No associations were seen for girls.ConclusionMMR may have a protective effect against childhood asthma for boys. This calls for an understanding of whether non-specific effects of vaccines can be used to optimize our vaccine programmes.
- Subjects :
- 0301 basic medicine
Male
Pediatrics
medicine.medical_specialty
Epidemiology
Denmark
heterologous
immunization
Vaccines, Attenuated
Rubella
Measles
complex mixtures
03 medical and health sciences
0302 clinical medicine
trained innate immunity
medicine
measles
Humans
Cumulative incidence
030212 general & internal medicine
Diphtheria-Tetanus-Pertussis Vaccine
Immunization Schedule
Asthma
Haemophilus Vaccines
Vaccines, Conjugate
business.industry
Tetanus
Diphtheria
Incidence (epidemiology)
non-specific effects of vaccines
Infant
General Medicine
vaccine sequence
asthma
medicine.disease
immunity
infant
Poliomyelitis
Poliovirus Vaccine, Inactivated
030104 developmental biology
Child, Preschool
mumps and rubella vaccine
Female
business
Measles-Mumps-Rubella Vaccine
Subjects
Details
- ISSN :
- 14643685
- Volume :
- 48
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of epidemiology
- Accession number :
- edsair.doi.dedup.....a0f673cc67c3024f42ee60ebfb01f364