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Dietary calcium, magnesium, and phosphorus intakes and risk of stroke in Chinese adults
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Controversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Ptrend = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pinteraction = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, Ptrend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men.
- Subjects :
- 0301 basic medicine
Male
Diseases
030204 cardiovascular system & hematology
0302 clinical medicine
Surveys and Questionnaires
Medicine
Magnesium
Stroke
Multidisciplinary
Incidence
Hazard ratio
Phosphorus
Middle Aged
Nutrition Surveys
household food inventory
Quartile
Chinese adults
Female
China
Science
chemistry.chemical_element
Nutritional Status
Calcium
Lower risk
Article
03 medical and health sciences
Asian People
Humans
stroke incidence
Aged
Proportional Hazards Models
Retrospective Studies
030109 nutrition & dietetics
business.industry
Proportional hazards model
medicine.disease
Confidence interval
Diet
Calcium, Dietary
chemistry
Risk factors
Dietary Supplements
Phosphorus, Dietary
business
diet
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....a0f5cea1e060fb9606c52fe2de1ce531