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A Comprehensive Overview on Stress Neurobiology:Basic Concepts and Clinical Implications
- Source :
- Godoy, L D, Rossignoli, M T, Delfino-Pereira, P, Garcia-Cairasco, N & de Lima Umeoka, E H 2018, ' A Comprehensive Overview on Stress Neurobiology : Basic Concepts and Clinical Implications ', Frontiers in Behavioral Neuroscience, vol. 12, pp. 127 . https://doi.org/10.3389/fnbeh.2018.00127, Frontiers in Behavioral Neuroscience, Frontiers in Behavioral Neuroscience, Vol 12 (2018), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2018
-
Abstract
- Stress is recognized as an important issue in basic and clinical neuroscience research, based upon the founding historical studies by Walter Canon and Hans Selye in the past century, when the concept of stress emerged in a biological and adaptive perspective. A lot of research after that period has expanded the knowledge in the stress field. Since then, it was discovered that the response to stressful stimuli is elaborated and triggered by the, now known, stress system, which integrates a wide diversity of brain structures that, collectively, are able to detect events and interpret them as real or potential threats. However, different types of stressors engage different brain networks, requiring a fine-tuned functional neuroanatomical processing. This integration of information from the stressor itself may result in a rapid activation of the Sympathetic-Adreno-Medullar (SAM) axis and the Hypothalamus-Pituitary-Adrenal (HPA) axis, the two major components involved in the stress response. The complexity of the stress response is not restricted to neuroanatomy or to SAM and HPA axes mediators, but also diverge according to timing and duration of stressor exposure, as well as its short- and/or long-term consequences. The identification of neuronal circuits of stress, as well as their interaction with mediator molecules over time is critical, not only for understanding the physiological stress responses, but also to understand their implications on mental health.
- Subjects :
- 0301 basic medicine
neuroanatomy
Cognitive Neuroscience
NEUROANATOMIA
Review
lcsh:RC321-571
physical and psychological stressors
Fight-or-flight response
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Stress (linguistics)
SAM axis
medicine
clinical implications of stress
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Physiological Stress Responses
HPA axis
Stressor
Perspective (graphical)
HPA axis time-domain
stress response
Stress field
030104 developmental biology
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
stress history
Identification (biology)
Psychology
Neuroscience
030217 neurology & neurosurgery
Neuroanatomy
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Godoy, L D, Rossignoli, M T, Delfino-Pereira, P, Garcia-Cairasco, N & de Lima Umeoka, E H 2018, ' A Comprehensive Overview on Stress Neurobiology : Basic Concepts and Clinical Implications ', Frontiers in Behavioral Neuroscience, vol. 12, pp. 127 . https://doi.org/10.3389/fnbeh.2018.00127, Frontiers in Behavioral Neuroscience, Frontiers in Behavioral Neuroscience, Vol 12 (2018), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Accession number :
- edsair.doi.dedup.....a0e4ffcce029483f273359767cd79f1b