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Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)
- Source :
- Molecules, Molecules, Vol 26, Iss 1150, p 1150 (2021), Volume 26, Issue 4
- Publication Year :
- 2021
-
Abstract
- A novel series of 4-(4-formamidophenylamino)-N-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT116) at low micromolar concentrations and the most potent analog 5q possessed broad-spectrum antiproliferative activity. Experiments in vivo demonstrated that 5q could effectively prolong the longevity of colon carcinoma-burdened mice and slow down the progression of cancer cells by suppression of angiogenesis and the induction of apoptosis and necrosis.
- Subjects :
- Necrosis
Angiogenesis
Pharmaceutical Science
Antineoplastic Agents
Apoptosis
Article
Analytical Chemistry
lcsh:QD241-441
anti-proliferation
03 medical and health sciences
Mice
0302 clinical medicine
lcsh:Organic chemistry
In vivo
Drug Discovery
medicine
Tumor Cells, Cultured
Animals
Humans
Physical and Theoretical Chemistry
4-(4-formamidophenylamino)-N-methylpicolinamide derivatives
Picolinic Acids
030304 developmental biology
Biological evaluation
Cell Proliferation
0303 health sciences
Mice, Inbred BALB C
Chemistry
Organic Chemistry
angiogenesis inhibitors
Neoplasms, Experimental
In vitro
Chemistry (miscellaneous)
Cell culture
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Molecular Medicine
Female
pharmacology
medicine.symptom
Drug Screening Assays, Antitumor
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....a0c6f6d156e6f8d3006d46a9d28e8365