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Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors
- Source :
- Journal of the American Chemical Society. 124:11852-11853
- Publication Year :
- 2002
- Publisher :
- American Chemical Society (ACS), 2002.
-
Abstract
- Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of ACE2 were designed and synthesized.
- Subjects :
- Stereochemistry
Angiotensin-Converting Enzyme Inhibitors
Carboxypeptidases
Peptidyl-Dipeptidase A
Biochemistry
Catalysis
Carboxypeptidase activity
Structure-Activity Relationship
Colloid and Surface Chemistry
Glutamate carboxypeptidase II
Structure–activity relationship
chemistry.chemical_classification
biology
Chemistry
Imidazoles
Rational design
Succinates
Angiotensin-converting enzyme
General Chemistry
Carboxypeptidase
Protein Structure, Tertiary
Enzyme
Drug Design
Angiotensin-converting enzyme 2
biology.protein
Angiotensin-Converting Enzyme 2
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....a0ae8e267715c9ef3c7da7ac60af86b2
- Full Text :
- https://doi.org/10.1021/ja0277226