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Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease
- Source :
- Van Limbergent, J, Russell, R K, Drummond, H E, Aldhous, M C, Round, N K, Nimmo, E R, Smith, L, Gillett, P M, McGrogan, P, Weaver, L T, Bisset, W M, Mahdi, G, Arnott, I D, Satsangi, J & Wilson, D 2008, ' Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease ', Gastroenterology, vol. 135, no. 4, pp. 1114-1122 . https://doi.org/10.1053/j.gastro.2008.06.081
- Publication Year :
- 2008
-
Abstract
- Background & Aims: Childhood-onset inflammatory bowel disease (IBD) might be etiologically different from adult-onset IBD. We analyzed disease phenotypes and progression of childhood-onset disease and compared them with characteristics of adult-onset disease in patients in Scotland. Methods: Anatomic locations and behaviors were assessed in 416 patients with childhood-onset (276 Crohn's disease [CD], 99 ulcerative colitis [UC], 41 IBD type unclassified [IBDU] diagnosed before seventeenth birthday) and 1297 patients with adult-onset (596 CD, 701 UC) IBD using the Montreal classification. Results: At the time of diagnosis in children, CD involved small bowel and colon (L3) in 51% (138/273), colon (L2) in 36%, and ileum (M) in 6%; the upper gastrointestinal (GI) tract (L4) was also affected in 51%. In 39%, the anatomic extent increased within 2 years. Behavioral characteristics progressed; 24% of children developed stricturing or penetrating complications within 4 years (vs 9% at diagnosis; P < .0001; odds ratio [OR], 3.32; 95% confidence interval [CI], 1.86 - 5.92). Compared with adults, childhood-onset disease was characterized by a "panenteric" phenotype (ileocolonic plus upper GI [L3 + L4]; 43% vs 3%; P
- Subjects :
- Adult
Male
Scotland/epidemiology
medicine.medical_specialty
Adolescent
Ileum
Disease
Kaplan-Meier Estimate
Inflammatory bowel disease
Gastroenterology
Crohn Disease
Internal medicine
Prevalence
Medicine
Humans
Immunologic Factors
Colitis
Age of Onset
Child
Digestive System Surgical Procedures
Hepatology
business.industry
Odds ratio
Middle Aged
medicine.disease
Immunologic Factors/therapeutic use
Ulcerative colitis
Phenotype
digestive system diseases
medicine.anatomical_structure
Scotland
Disease Progression
Colitis, Ulcerative
Female
Age of onset
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15280012
- Volume :
- 135
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....a08259cfafe7e18f617646328453d276