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[Antibodies to N-homocysteinylated albumin in patients with systemic lupus erythematosus]
- Source :
- Polskie Archiwum Medycyny Wewnetrznej. 117(3)
- Publication Year :
- 2007
-
Abstract
- INTRODUCTION Hyperhomocysteinemia is known to predispose to atherosclerosis and occurs more commonly in patients with systemic lupus erythematosus (SLE) than in the general population. It has been shown that elevated plasma total homocysteine (tHcy) results in protein N-homocysteinylation and production o autoantibodies against N-homocysteinylated (N-Hcy) proteins. OBJECTIVES The aim of the study was to investigate whether anti-N-Hcy-albumin antibodies occur in patients with SLE and identify factors that determine these antibodies in such population. Patients and methods. In 50 subjects with SLE and 50 age- and sex-matched healthy controls, we determined serum IgG antibodies to N-Hcy-albumin using an in-house enzyme linked immunosorbent assay. RESULTS Patients had higher plasma tHcy and C-reactive protein (CRP) than controls, while serum folate and witamin B12 were lower in patients. Levels of anti-N-Hcy-albumin were higher in patients with SLE than in controls (medians: 0.31; vs. 0.19; p < 0.0001). In SLE patients, levels of anti- N-Hcy-albumin antibodies correlated with tHcy (r = 0.83; p
- Subjects :
- Adult
Male
Hyperhomocysteinemia
medicine.medical_specialty
Anti-nuclear antibody
Adolescent
Population
Gastroenterology
Folic Acid
systemic lupus erythematosus
Internal medicine
Internal Medicine
medicine
Humans
Lupus Erythematosus, Systemic
antibodies to N-homocysteinylated albumin
education
Homocysteine
Serum Albumin
Autoantibodies
education.field_of_study
Lupus erythematosus
biology
business.industry
Case-control study
Autoantibody
homocysteine
Middle Aged
medicine.disease
Vitamin B 12
C-Reactive Protein
Case-Control Studies
biology.protein
Female
Antibody
business
Anti-SSA/Ro autoantibodies
Subjects
Details
- Volume :
- 117
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Polskie Archiwum Medycyny Wewnetrznej
- Accession number :
- edsair.doi.dedup.....a07f8539b21b0f90ba48457e1efd17d5