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Similar neurocognitive outcomes after 48 weeks in HIV-1-infected participants randomized to continue tenofovir/emtricitabine + atazanavir/ritonavir or simplify to abacavir/lamivudine + atazanavir
- Source :
- Journal of Neurovirology
- Publication Year :
- 2018
- Publisher :
- Springer International Publishing, 2018.
-
Abstract
- Human immunodeficiency virus (HIV)-associated neurocognitive disorders can persist in many patients despite achieving viral suppression while on antiretroviral therapy (ART). Neurocognitive function over 48 weeks was evaluated using a Cogstate test battery assessing psychomotor function, attention, learning, and working memory in 293 HIV-1-infected, ART-experienced, and virologically suppressed adults. The ASSURE study randomized participants 1:2 to remain on tenofovir/emtricitabine (TDF/FTC) and ritonavir-boosted atazanavir (ATV/r) or simplify to abacavir/lamivudine + atazanavir (ABC/3TC + ATV). Neurocognitive z-scores were computed using demographically adjusted normative data and were classified as “impaired” (defined as either a z-score ≤ − 2 or having 2 or more standardized individual test z-scores ≤ − 1); while higher scores (equaling better performance) were classified as “normal”. By z-scores, 54.7% of participants had impaired neurocognition at baseline and 50.2% at week 48. There were no significant differences (p
- Subjects :
- 0301 basic medicine
CD4-Positive T-Lymphocytes
Male
HIV Infections
Neuropsychological Tests
HIV-associated neurocognitive disorder
0302 clinical medicine
Cognition
Abacavir
Antiretroviral Therapy, Highly Active
Emtricitabine
Prospective Studies
Cogstate
education.field_of_study
Lamivudine
Middle Aged
Computerized battery
Drug Combinations
Memory, Short-Term
Neurology
Female
medicine.drug
Adult
medicine.medical_specialty
Population
Atazanavir Sulfate
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
Virology
Internal medicine
medicine
Humans
education
Tenofovir
Aged
Psychomotor function
Ritonavir
business.industry
HIV-cognitive disorder
Interleukin-6
HIV
Abacavir/Lamivudine
medicine.disease
Dideoxynucleosides
Atazanavir
CD4 Lymphocyte Count
030104 developmental biology
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15382443 and 13550284
- Volume :
- 25
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Neurovirology
- Accession number :
- edsair.doi.dedup.....a078c144e33c2fa7083d77048d43192c