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Inadvertent High-dose Therapy With Temozolomide in a Child With Recurrent Pontine Glioma Followed by a Rapid Clinical Response But Deteriorated After Substitution With Low-dose Therapy
- Source :
- Journal of Pediatric Hematology/Oncology. 36:e549-e552
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- We present a case of inadvertent high-dose therapy with temozolomide in a child with recurrent diffuse intrinsic pontine glioma followed by a rapid clinical response. The patient was a 7-year-old boy who initially presented with a history of left facial palsy, double vision, headache, and ataxia. His symptoms were completely resolved following radiotherapy but recurred 3 months after. Following recurrence, he received temozolomide in a dose >3 times higher than prescribed inadvertently but tolerated well with a rapid clinical response. He eventually deteriorated after he was substituted with a lower dose of temozolomide and died.
- Subjects :
- Male
medicine.medical_specialty
Ataxia
medicine.medical_treatment
Fatal Outcome
Neoplasm Recurrence
Temozolomide
medicine
Brain Stem Neoplasms
Humans
Child
Antineoplastic Agents, Alkylating
Palsy
Dose-Response Relationship, Drug
business.industry
Low dose
Glioma
Hematology
Pontine glioma
Surgery
Dacarbazine
Radiation therapy
High dose therapy
Oncology
Pediatrics, Perinatology and Child Health
Neoplasm Recurrence, Local
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 10774114
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Hematology/Oncology
- Accession number :
- edsair.doi.dedup.....a0769997766cb97ae6d82e784f53d090