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Oral probiotic VSL#3 attenuates the circulatory disturbances of patients with cirrhosis and ascites
- Source :
- Liver International. 34:1504-1512
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Background & Aims The modulation of gut flora constitutes a therapeutic tool in patients with liver disease, but some of its modalities require further investigation. Here, we evaluated the effects of probiotics on the hepatic and systemic haemodynamic alterations of advanced liver disease. Methods Seventeen patients with cirrhosis and ascites were prospectively included, five of whom abandoned this study prematurely. Hepatic and systemic haemodynamic evaluations were performed at baseline and after 6 weeks of receiving an oral VSL#3 probiotic preparation. Peripheral blood analyses included the evaluation of cytokines (TNF-alpha, IL-1beta, IL-6), bacterial translocation [bacterial DNA and lipopolysaccharide-binding protein (LBP)] and nitric oxide end-products (NOx). Results In 12 patients completing this study, the oral administration of VSL#3 resulted in reductions of the hepatic venous pressure gradient (HVPG, P
- Subjects :
- Adult
DNA, Bacterial
Liver Cirrhosis
medicine.medical_specialty
Cirrhosis
Portal venous pressure
Molecular Sequence Data
Administration, Oral
Gastroenterology
Statistics, Nonparametric
Liver disease
Heart Rate
Oral administration
RNA, Ribosomal, 16S
Internal medicine
Ascites
medicine
Humans
Prospective Studies
Aged
DNA Primers
Membrane Glycoproteins
Base Sequence
Hepatology
business.industry
Probiotics
Sodium
Hemodynamics
Sequence Analysis, DNA
Middle Aged
medicine.disease
Surgery
medicine.anatomical_structure
Spain
Hyperdynamic circulation
Vascular resistance
Cytokines
Portal hypertension
Vascular Resistance
medicine.symptom
Carrier Proteins
business
Venous Pressure
Acute-Phase Proteins
Subjects
Details
- ISSN :
- 14783223
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Liver International
- Accession number :
- edsair.doi.dedup.....a070bf53944e2b1adc68a49d19b5dde8