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Strong relationship between NT-proXNP levels and cardiac output following cardiac surgery in neonates and infants
- Source :
- Acta Anaesthesiologica Scandinavica. 54:502-509
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Background: NT-proXNP, a new natriuretic peptide analyte, incorporates information about the concentrations of both N-terminal pro-atrial and pro-brain natriuretic peptides (NT-proANP, NT-proBNP). We aimed to investigate whether NT-proXNP is a reliable indicator of the cardiac index (CI) and the hemodynamic state in neonates and infants undergoing an open heart surgery. Methods: We enrolled 26 children under the age of 1 year into this prospective study. All patients underwent an elective cardiac operation with cardiopulmonary bypass (CPB) to achieve complete biventricular repair. Peri-operative hemodynamic parameters were assessed by transpulmonary thermodilution and natriuretic peptide levels were recorded. Results: The NT-proXNP level correlated significantly with the simultaneously measured NT-proANP level (r = 0.60, P < 0.001), but more strongly with the NT-proBNP level (r = 0.89, P < 0.001) and the arithmetic sum of both (r = 0.88, P < 0.001). NT-proXNP had a strong correlation with CI (r = ― 0.85, P < 0.001), the stroke volume index (r = ― 0.80, P < 0.001) and the global ejection fraction (r = ― 0.67, P < 0.009) throughout the post-operative period. Conventionally measured parameters such as heart rate, mean arterial pressure and pulse-pressure product exhibited weaker correlations with CI than NT-proXNP. Among laboratory values, creatinine levels correlated significantly with CI (r = ― 0.77, P
- Subjects :
- Heart Defects, Congenital
Male
X-linked Nuclear Protein
Cardiac output
medicine.medical_specialty
Mean arterial pressure
medicine.drug_class
Heart Ventricles
Thermodilution
Cardiac index
Electrocardiography
Heart Rate
Heart rate
medicine
Natriuretic peptide
Humans
Postoperative Period
Prospective Studies
Cardiac Output
Cardiac Surgical Procedures
Protein Precursors
Ejection fraction
business.industry
DNA Helicases
Hemodynamics
Infant, Newborn
Infant
Nuclear Proteins
Stroke Volume
General Medicine
Stroke volume
Cardiac surgery
Anesthesiology and Pain Medicine
Creatinine
Anesthesia
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 13996576 and 00015172
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Acta Anaesthesiologica Scandinavica
- Accession number :
- edsair.doi.dedup.....a05ec96175fcaf09c1df6dc97c3e98f2