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Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury

Authors :
Agnete Larsen
P. Doering
Meredin Stoltenberg
Mie Østergaard Pedersen
Gorm Danscher
Dan Sonne Pedersen
Milena Penkowa
Kristian Kolind
Source :
Larsen, A, Kolind, K, Pedersen, D S, Doering, P, Pedersen, M O, Danscher, G, Penkowa, M & Stoltenberg, M 2008, ' Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury ', Histochemistry and Cell Biology, vol. 130, no. 4, pp. 681-92 . https://doi.org/10.1007/s00418-008-0448-1
Publication Year :
2008

Abstract

Udgivelsesdato: 2008-Oct Traumatic brain injury results in loss of neurons caused as much by the resulting neuroinflammation as by the injury. Gold salts are known to be immunosuppressive, but their use are limited by nephrotoxicity. However, as we have proven that implants of pure metallic gold release gold ions which do not spread in the body, but are taken up by cells near the implant, we hypothesize that metallic gold could reduce local neuroinflammation in a safe way. Bio-liberation, or dissolucytosis, of gold ions from metallic gold surfaces requires the presence of disolycytes i.e. macrophages and the process is limited by their number and activity. We injected 20-45 mum gold particles into the neocortex of mice before generating a cryo-injury. Comparing gold-treated and untreated cryolesions, the release of gold reduced microgliosis and neuronal apoptosis accompanied by a transient astrogliosis and an increased neural stem cell response. We conclude that bio-liberated gold ions possess pronounced anti-inflammatory and neuron-protective capacities in the brain and suggest that metallic gold has clinical potentials. Intra-cerebral application of metallic gold as a pharmaceutical source of gold ions represents a completely new medical concept that bypasses the blood-brain-barrier and allows direct drug delivery to inflamed brain tissue.

Details

ISSN :
09486143
Volume :
130
Issue :
4
Database :
OpenAIRE
Journal :
Histochemistry and cell biology
Accession number :
edsair.doi.dedup.....a059189cfca8d40836a434a62761bacb
Full Text :
https://doi.org/10.1007/s00418-008-0448-1