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Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury
- Source :
- Larsen, A, Kolind, K, Pedersen, D S, Doering, P, Pedersen, M O, Danscher, G, Penkowa, M & Stoltenberg, M 2008, ' Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury ', Histochemistry and Cell Biology, vol. 130, no. 4, pp. 681-92 . https://doi.org/10.1007/s00418-008-0448-1
- Publication Year :
- 2008
-
Abstract
- Udgivelsesdato: 2008-Oct Traumatic brain injury results in loss of neurons caused as much by the resulting neuroinflammation as by the injury. Gold salts are known to be immunosuppressive, but their use are limited by nephrotoxicity. However, as we have proven that implants of pure metallic gold release gold ions which do not spread in the body, but are taken up by cells near the implant, we hypothesize that metallic gold could reduce local neuroinflammation in a safe way. Bio-liberation, or dissolucytosis, of gold ions from metallic gold surfaces requires the presence of disolycytes i.e. macrophages and the process is limited by their number and activity. We injected 20-45 mum gold particles into the neocortex of mice before generating a cryo-injury. Comparing gold-treated and untreated cryolesions, the release of gold reduced microgliosis and neuronal apoptosis accompanied by a transient astrogliosis and an increased neural stem cell response. We conclude that bio-liberated gold ions possess pronounced anti-inflammatory and neuron-protective capacities in the brain and suggest that metallic gold has clinical potentials. Intra-cerebral application of metallic gold as a pharmaceutical source of gold ions represents a completely new medical concept that bypasses the blood-brain-barrier and allows direct drug delivery to inflamed brain tissue.
- Subjects :
- Pathology
medicine.medical_specialty
Histology
Surface Properties
Anti-Inflammatory Agents
Apoptosis
Microgliosis
Metal
Mice
medicine
Animals
Particle Size
Molecular Biology
Neuroinflammation
Inflammation
Neurons
Microglia
Chemistry
Cell Biology
medicine.disease
Neuroregeneration
Neural stem cell
Astrogliosis
Nerve Regeneration
Mice, Inbred C57BL
Medical Laboratory Technology
medicine.anatomical_structure
visual_art
Brain Injuries
Gold salts
visual_art.visual_art_medium
Biophysics
Female
Gold
medicine.drug
Subjects
Details
- ISSN :
- 09486143
- Volume :
- 130
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Histochemistry and cell biology
- Accession number :
- edsair.doi.dedup.....a059189cfca8d40836a434a62761bacb
- Full Text :
- https://doi.org/10.1007/s00418-008-0448-1