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Volume of cerebellar vermis in monozygotic twins discordant for combat exposure: Lack of relationship to post-traumatic stress disorder
- Source :
- Psychiatry Research: Neuroimaging. 148:143-149
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Several functional neuroimaging studies have implicated the cerebellar vermis in post-traumatic stress disorder (PTSD), but there have been no structural neuroimaging studies of this brain structure in PTSD. We utilized magnetic resonance imaging (MRI) with manual tracing to quantify the volumes of three divisions of the mid-sagittal vermis, and their total, within an identical, co-twin control design that employed Vietnam veterans discordant for combat exposure in Vietnam. Each structure's volume was significantly correlated between twins, indicating a partial familial determination: for anterior superior vermis, r=0.73; for posterior superior vermis, r=0.47; for inferior posterior vermis, r=0.51; and for total vermis, r=0.57. There were no significant differences between the PTSD and non-PTSD veterans for any vermis volume, and no significant main effects or interactions when their non-combat-exposed co-twins were added to the analyses. Thus, the results do not support the structural abnormality of cerebellar vermis in combat-related PTSD.
- Subjects :
- Male
Cerebellum
Neuroscience (miscellaneous)
Monozygotic twin
Article
Neuroimaging
Reference Values
Functional neuroimaging
Diseases in Twins
Image Processing, Computer-Assisted
medicine
Humans
Radiology, Nuclear Medicine and imaging
Veterans
Combat Disorders
medicine.diagnostic_test
Magnetic resonance imaging
Twins, Monozygotic
Anatomy
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
Cerebellar vermis
Abnormality
Psychology
Neuroscience
Anxiety disorder
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....a03806f3b4d72428092f28f1b49a2077