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The Cancer Genome Atlas expression profiles of low-grade gliomas
- Source :
- Neurosurgical focus. 36(4)
- Publication Year :
- 2014
-
Abstract
- Differentiating between low-grade gliomas (LGGs) of astrocytic and oligodendroglial origin remains a major challenge in neurooncology. Here the authors analyzed The Cancer Genome Atlas (TCGA) profiles of LGGs with the goal of identifying distinct molecular characteristics that would afford accurate and reliable discrimination of astrocytic and oligodendroglial tumors. They found that 1) oligodendrogliomas are more likely to exhibit the glioma-CpG island methylator phenotype (G-CIMP), relative to low-grade astrocytomas; 2) relative to oligodendrogliomas, low-grade astrocytomas exhibit a higher expression of genes related to mitosis, replication, and inflammation; and 3) low-grade astrocytic tumors harbor microRNA profiles similar to those previously described for glioblastoma tumors. Orthogonal intersection of these molecular characteristics with existing molecular markers, such as IDH1 mutation, TP53 mutation, and 1p19q status, should facilitate accurate and reliable pathological diagnosis of LGGs.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Oligoastrocytoma
Oligodendroglioma
Biology
microRNA
medicine
Humans
Oligodendroglial Tumor
RNA, Messenger
neoplasms
Gene
Genetic Association Studies
Oligonucleotide Array Sequence Analysis
Brain Neoplasms
Gene Expression Profiling
Neurooncology
Astrocytoma
General Medicine
Glioma
DNA Methylation
medicine.disease
Isocitrate Dehydrogenase
nervous system diseases
Gene expression profiling
Gene Expression Regulation, Neoplastic
MicroRNAs
Mutation
Surgery
CpG Islands
Female
Neurology (clinical)
Tumor Suppressor Protein p53
Subjects
Details
- ISSN :
- 10920684
- Volume :
- 36
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Neurosurgical focus
- Accession number :
- edsair.doi.dedup.....a028436fa4eb2e0c1defba1346cd1e42