Back to Search
Start Over
Do human embryos have the ability of self-correction?
- Source :
- Reproductive Biology and Endocrinology, Vol 18, Iss 1, Pp 1-6 (2020), Reproductive Biology and Endocrinology : RB&E
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Human embryogenesis frequently coinciding with cell division mistakes contributing to pervasive embryonic aneuploidy/mosaicism. While embryo self-correction was elegantly demonstrated in mouse models, human studies are lacking. Here we are witness to human embryos ability to eliminate/expel abnormal blastomeres as cell debris/fragments. Each blastocyst and its corresponding debris were separated and underwent whole genome amplification. Seven of the 11 pairs of blastocysts and their corresponding cell debris/fragments revealed discordant results. Of the 9 euploid blastocysts, four showed euploid debris, while in the others, the debris were aneuploid. In the remaining pairs, the debris showed additional aneuploidy to those presented by their corresponding blastocyst. The observed ability of human embryos to self-correction doubts many invasive and non-invasive preimplantation testing for aneuploidy at the blastocyst stage, rendering high rate of false positive (discarding “good” embryos) by identifying the cell-free DNA originated from the expelled cell debris, as aneuploidy/mosaic blastocyst.
- Subjects :
- Adult
Male
0301 basic medicine
Cell division
lcsh:QH471-489
Biopsy
Embryonic Development
Aneuploidy
Fertilization in Vitro
Biology
lcsh:Gynecology and obstetrics
Self-correction
Embryo Culture Techniques
Andrology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Cell-Derived Microparticles
medicine
Humans
Human embryogenesis
Human embryo
lcsh:Reproduction
Embryo Implantation
Genetic Testing
Blastocyst
Cells, Cultured
Preimplantation Diagnosis
lcsh:RG1-991
Comparative Genomic Hybridization
030219 obstetrics & reproductive medicine
Mosaicism
Research
Genetic Diseases, Inborn
High-Throughput Nucleotide Sequencing
Obstetrics and Gynecology
Embryo
Blastomere
medicine.disease
Embryonic stem cell
PGT
030104 developmental biology
medicine.anatomical_structure
Reproductive Medicine
embryonic structures
Female
Ploidy
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14777827
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Reproductive Biology and Endocrinology
- Accession number :
- edsair.doi.dedup.....a022a6aeb70cce71e8abed6de2175dbd