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Aerobic training prevents dexamethasone-induced peripheral insulin resistance
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2014
-
Abstract
- This study investigated how proteins of the insulin signaling cascade could modulate insulin resistance after dexamethasone (Dexa) treatment and aerobic training. Rats were distributed into 4 groups: sedentary control (SC), sedentary+Dexa (SD), trained control (TC), and trained+Dexa (TD), and underwent aerobic training for 70 days or remained sedentary. Dexa was administered during the last 10 days (1 mg · kg −1 per day i. p.). After 70 days, an intraperitoneal glucose tolerance test (ipGTT) was performed. Protein levels of IRS-1, AKT, and PKC-α in the tibialis anterior (TA) muscle were identified using Western blots. Dexa treatment increased blood glucose and the area under the curve (AUC) of ipGTT. Training attenuated the hyperglycemia and the AUC induced by Dexa. Dexa reduced IRS-1 (− 16%) and AKT (− 43%) protein level with no changes in PKC-α levels. Moreover, these effects on IRS-1 and AKT protein level were prevented in trained animals. These results show for the first time that aerobic exercise prevented reductions of IRS-1 and AKT level induced by Dexa in the TA muscle, suggesting that aerobic exercise is a good strategy to prevent Dexa-induced peripheral insulin resistance.
- Subjects :
- musculoskeletal diseases
Blood Glucose
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Blotting, Western
MÚSCULO ESQUELÉTICO
Biochemistry
Dexamethasone
Endocrinology
Insulin resistance
Internal medicine
Physical Conditioning, Animal
Medicine
Aerobic exercise
Animals
Phosphorylation
Rats, Wistar
Protein kinase B
Glucose tolerance test
medicine.diagnostic_test
biology
business.industry
Muscles
Biochemistry (medical)
Body Weight
Area under the curve
Skeletal muscle
General Medicine
Organ Size
Glucose Tolerance Test
musculoskeletal system
medicine.disease
Rats
Insulin receptor
medicine.anatomical_structure
biology.protein
Insulin Receptor Substrate Proteins
Insulin Resistance
business
medicine.drug
Subjects
Details
- ISSN :
- 14394286
- Volume :
- 46
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- Accession number :
- edsair.doi.dedup.....a01bbd324018902535e82a56de126c8e