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Altered Oxygen Metabolic Conditions Associated With Increased Norepinephrine Levels in a Nonpulsatile Systemic Circulation
- Source :
- ASAIO JOURNAL. 42:M854-857
- Publication Year :
- 1996
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1996.
-
Abstract
- Change in oxygen metabolic conditions accompanying the conversion of systemic flow from pulsatile to nonpulsatile (from P-mode to N-mode) was investigated in association with blood norepinephrine levels. Total left heart bypass was instituted through a left thoracotomy under general anesthesia in 10 adult goats. Pulsatile and nonpulsatile pumps were incorporated in the circuit in parallel, and the flow character was rapidly converted from the P-mode to the N-mode. Norepinephrine levels increased significantly after the conversion, from 222 +/- 54 pg/ml to 285 +/- 65 pg/ml. While oxygen delivery (DO2) was kept constant, the oxygen extraction ratio significantly decreased, from 21 +/- 3% to 16 +/- 3%, and venous oxygen saturation (SvO2) significantly increased, from 77 +/- 6% to 84 +/- 6% after depulsation. The serum lactate level was significantly higher in the N-mode than the P-mode (P-mode: 35 +/- 2 mg/dl, N-mode: 45 +/- 5 mg/dl). Strong positive and negative correlations of norepinephrine levels were observed with oxygen extraction ratio and SvO2, respectively, whereas norepinephrine levels did not correlated with DO2. Regression lines in these correlations unveiled higher oxygen uptake in the P-mode than the N-mode at the same norepinephrine level. These results indicate that, in the setting of an acute animal experiment, oxygen uptake is less efficient with the absence of pulsatility, and the higher norepinephrine concentration functioned to tune the oxygen metabolism in the initial stage of nonpulsatile systemic circulation.
- Subjects :
- medicine.medical_specialty
Biomedical Engineering
Biophysics
Pulsatile flow
chemistry.chemical_element
Bioengineering
Oxygen
Systemic circulation
Biomaterials
Norepinephrine (medication)
Hemoglobins
Norepinephrine
Internal medicine
medicine
Animals
Heart bypass
Chemistry
Goats
Oxygen metabolism
Hemodynamics
General Medicine
Carbon Dioxide
Oxygen uptake
Endocrinology
Evaluation Studies as Topic
Pulsatile Flow
Heart-Assist Devices
Serum lactate level
medicine.drug
Subjects
Details
- ISSN :
- 10582916
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- ASAIO JOURNAL
- Accession number :
- edsair.doi.dedup.....a0144802ccadff67cd75c90add3bac5e