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Construction of a near-infrared fluorescent probe for ratiometric imaging of peroxynitrite during tumor progression

Authors :
Lu Jiao
Jinmao You
Qing Pang
Li Zan
Source :
The Analyst. 146:5204-5211
Publication Year :
2021
Publisher :
Royal Society of Chemistry (RSC), 2021.

Abstract

Malignant tumors are one of the main causes for human death and are tightly associated with overexpression of reactive oxygen species (ROS) in pathological processes. Therefore, in vivo monitoring of ROS, especially ONOO-, remains of great significance for diagnosis and therapy of tumors to improve the survival rate. Herein, we designed and constructed a reliable near-infrared (NIR) ratiometric fluorescent biosensor CDMS for monitoring the fluctuations of ONOO- in the process of tumor progression. CDMS featured outstanding stability to photoirradiation, substantial quantum yields, rapid response (

Details

ISSN :
13645528 and 00032654
Volume :
146
Database :
OpenAIRE
Journal :
The Analyst
Accession number :
edsair.doi.dedup.....a00a7a93fd9ab5298274c6e2a7fcafff