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Fatal obstructive lung disease after haploidentical sibling cord blood transplantation
- Source :
- Bone Marrow Transplantation. 21:939-941
- Publication Year :
- 1998
- Publisher :
- Springer Science and Business Media LLC, 1998.
-
Abstract
- We report the case of a patient with fatal obstructive lung disease after an HLA-haploidentical sibling cord blood transplant (CBT), with severe acute GVHD. A 2-year-old girl developed expiratory air trapping gradually with acute and chronic GVHD after CBT for the treatment of ALL. Anti-CMV and immunosuppressive therapy were ineffective, and the patient died of progressive respiratory acidosis. Necropsy of the lung revealed severe bronchiolitis obliterans with cytomegalic inclusion cells in the granulation tissues of the bronchiolitis. Thus, immunologic and GVHD problems can occur even in CBT.
- Subjects :
- medicine.medical_specialty
Graft vs Host Disease
Bronchiolitis obliterans
Air trapping
Gastroenterology
Fatal Outcome
HLA Antigens
Acute lymphocytic leukemia
Internal medicine
medicine
Humans
Lung Diseases, Obstructive
Bronchiolitis Obliterans
Transplantation
Lung
business.industry
Respiratory disease
Hematopoietic Stem Cell Transplantation
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fetal Blood
medicine.disease
Obstructive lung disease
Surgery
surgical procedures, operative
medicine.anatomical_structure
Haplotypes
Bronchiolitis
Child, Preschool
Cord blood
Cytomegalovirus Infections
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....a005804dec31f214ac128bb5de5698b6