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Erythropoietin treatment in chemotherapy-induced anemia in previously untreated advanced esophagogastric cancer patients
- Source :
- International Journal of Clinical Oncology. 19:288-296
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- The impact of erythropoiesis-stimulating agents in chemotherapy-induced anemia has been a constant topic of debate over recent years. We prospectively assessed the efficacy of epoetin beta (Epo-b) in improving hemoglobin (Hb) levels and outcome in patients within an open label, randomized clinical phase II trial with advanced or metastatic gastric/esophagogastric cancer.Previously untreated patients were randomized to receive 3-weekly cycles of capecitabine (1000 mg/m(2) bid) for 14 days plus on day 1 either irinotecan 250 mg/m(2) or cisplatin 80 mg/m(2). Epo-b (30000 IU once weekly) was initiated in patients with Hb11 g/dl and continued until Hb ≥12 g/dl was reached. If after 4 weeks the Hb increase was0.5 g/dl, Epo-b was increased to 30000 IU, twice weekly.Of 118 patients enrolled, 32 received Epo-b treatment; of these, 65 % achieved an increase in Hb levels of at least 2 g/dl, with 74 % achieving the target Hb of ≥12 g/dl. Within the study population, patients receiving Epo-b showed better overall survival (median 14.5 vs. 8.0 months, P = 0.056) as well as a significantly improved disease control rate (78 vs. 55 %, P = 0.025). Patients in the irinotecan group profited significantly (P0.05) in terms of progression-free survival and overall survival under Epo-b treatment (median 6.5 vs 4.1 months and median 15.4 vs 8.4 months, respectively).Epo-b was effective in raising Hb levels in patients with advanced esophagogastric cancer. Patients receiving Epo-b had a significantly increased response to chemotherapy and a clear trend to improved survival.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Anemia
law.invention
Capecitabine
Hemoglobins
Randomized controlled trial
Stomach Neoplasms
law
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Prospective Studies
Prospective cohort study
Erythropoietin
Aged
Epoetin beta
business.industry
Hematology
General Medicine
Middle Aged
medicine.disease
Recombinant Proteins
Irinotecan
Clinical trial
Female
Surgery
Esophagogastric Junction
business
medicine.drug
Subjects
Details
- ISSN :
- 14377772 and 13419625
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....9ffd41c4fd028ebe4b5cc008999920a7
- Full Text :
- https://doi.org/10.1007/s10147-013-0544-7