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The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss
- Source :
- Journal of Exercise Nutrition & Biochemistry
- Publication Year :
- 2017
- Publisher :
- Korea Society for Exercise Nutrition, 2017.
-
Abstract
- [Purpose] Recent evidence suggests that regular exercise training plays a decisive role in maintaining homeostasis and promoting muscle and skeletal formation. However, the effect of downhill exercise training on osteogenesis-related factors is not well understood. [Methods] Thus, we investigated the effect of uphill and downhill training on ovariectomy (OVX)-induced bone loss. After ovary removal, the exercise method performed included uphill (16 m/min, +15°) and downhill training (16 m/min, –15°) for 60 min/day and 5 days/week, respectively, for 8 weeks. [Results] Our results showed that both uphill and downhill training significantly decreased the body weight, total cholesterol, and creatine kinase (CK) levels in the context of OVX-induced bone loss. On the contrary, levels of an osteogenesis indicator, osteocalcin and alkaline phosphatase were elevated. Consequently, the uphill and downhill training reduced OVX- induced bone loss in the distal femoral metaphysis. Likewise, the bone microstructure in OVX-induced bone loss was enhanced upon training. In particular, the inhibition of RANKL-induced osteoclast formation and osteoclast-specific gene expression improved upon downhill training compared to uphill training. [Conclusion] These results suggest that the uphill and downhill exercise types appeared to positively affect the expression of osteogenesis-related factors along with bone density and microstructure. Particularly, the downhill training has more beneficial effects on the maintenance of homeostasis during bone formation.
- Subjects :
- Trabecular bone
medicine.medical_specialty
Bone density
education
030209 endocrinology & metabolism
Context (language use)
03 medical and health sciences
0302 clinical medicine
Osteogenesis
Osteoclast
Internal medicine
Bone mineral density
medicine
biology
business.industry
Original Articles
Endocrinology
medicine.anatomical_structure
Bone formation
Osteocalcin
biology.protein
Ovariectomized rat
Alkaline phosphatase
Creatine kinase
business
030217 neurology & neurosurgery
Homeostasis
Subjects
Details
- ISSN :
- 22336842
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Exercise Nutrition & Biochemistry
- Accession number :
- edsair.doi.dedup.....9fdf7aab731eb581d340d04072bbe867