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Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- Glioblastoma (GBM) is the most aggressive type of brain tumors in adults with survival period
- Subjects :
- 0301 basic medicine
Vascular Endothelial Growth Factor A
Indoles
Protein Kinase C-alpha
Antineoplastic Agents
Biology
mTORC2
Article
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
medicine
Tumor Microenvironment
Humans
Neoplasm Invasiveness
Naphthyridines
Protein kinase C
PI3K/AKT/mTOR pathway
Phenylacetates
Sirolimus
Tumor microenvironment
Multidisciplinary
Brain Neoplasms
Tumor Necrosis Factor-alpha
TOR Serine-Threonine Kinases
RPTOR
NF-kappa B
Cell biology
Vascular endothelial growth factor A
030104 developmental biology
Matrix Metalloproteinase 9
Tumor progression
Purines
030220 oncology & carcinogenesis
Cancer research
Matrix Metalloproteinase 2
Glioblastoma
medicine.drug
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....9fd384d51f12cad76951399d14860c01