Syntheses of 2-Pyrones via Electrophilic Substitutions at C7 of 4-Hydroxy-6-methyl-2-pyrone through Mono- or Dianion Formation

Authors :: Jacob J. Swidorski
Jiashi Wang
R. Lizeth P. Munoz
Michael J. McLaughlin
Richard P. Hsung
Xuejun Zhang
Source :: Synthesis. 2007:749-753
Publication Year :: 2007
Publisher :: Georg Thieme Verlag KG, 2007.
Abstract: Electrophilic substitution protocols useful for functionalizations at C7 of 4-hydroxy-6-methyl-2-pyrone, or triacetic acid, are described here. This method was applied to the synthesis of annularin E.

Subjects :: chemistry.chemical_compound
Electrophilic substitution
chemistry
Stereochemistry
2-Pyrone
Organic Chemistry
Electrophile
General Medicine
Medicinal chemistry
Catalysis

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