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Toward Precision Medicine in ADHD
- Source :
- Frontiers in Behavioral Neuroscience, 16, Buitelaar, J, Bölte, S, Brandeis, D, Caye, A, Christmann, N, Cortese, S, Coghill, D, Faraone, S V, Franke, B, Gleitz, M, Greven, C U, Kooij, S, Leffa, D T, Rommelse, N, Newcorn, J H, Polanczyk, G V, Rohde, L A, Simonoff, E, Stein, M, Vitiello, B, Yazgan, Y, Roesler, M, Doepfner, M & Banaschewski, T 2022, ' Toward Precision Medicine in ADHD ', Frontiers in Behavioral Neuroscience, vol. 16, 900981 . https://doi.org/10.3389/fnbeh.2022.900981
- Publication Year :
- 2022
-
Abstract
- Contains fulltext : 281503.pdf (Publisher’s version ) (Open Access) Attention-Deficit Hyperactivity Disorder (ADHD) is a complex and heterogeneous neurodevelopmental condition for which curative treatments are lacking. Whilst pharmacological treatments are generally effective and safe, there is considerable inter-individual variability among patients regarding treatment response, required dose, and tolerability. Many of the non-pharmacological treatments, which are preferred to drug-treatment by some patients, either lack efficacy for core symptoms or are associated with small effect sizes. No evidence-based decision tools are currently available to allocate pharmacological or psychosocial treatments based on the patient's clinical, environmental, cognitive, genetic, or biological characteristics. We systematically reviewed potential biomarkers that may help in diagnosing ADHD and/or stratifying ADHD into more homogeneous subgroups and/or predict clinical course, treatment response, and long-term outcome across the lifespan. Most work involved exploratory studies with cognitive, actigraphic and EEG diagnostic markers to predict ADHD, along with relatively few studies exploring markers to subtype ADHD and predict response to treatment. There is a critical need for multisite prospective carefully designed experimentally controlled or observational studies to identify biomarkers that index inter-individual variability and/or predict treatment response.
- Subjects :
- 2805 Cognitive Neuroscience
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Cognitive Neuroscience
precision medicine
610 Medicine & health
10058 Department of Child and Adolescent Psychiatry
Attention-Deficit Hyperactivity Disorder (ADHD)
150 000 MR Techniques in Brain Function
ADHD, precision medicine
inter-individual variability
3206 Neuropsychology and Physiological Psychology
Behavioral Neuroscience
individual variability
Neuropsychology and Physiological Psychology
Deficit Hyperactivity Disorder (ADHD)
130 000 Cognitive Neurology & Memory
2802 Behavioral Neuroscience
biomarker
ADHD
Attention
inter
heterogeneity
Subjects
Details
- Language :
- English
- ISSN :
- 16625153
- Database :
- OpenAIRE
- Journal :
- Frontiers in Behavioral Neuroscience, 16, Buitelaar, J, Bölte, S, Brandeis, D, Caye, A, Christmann, N, Cortese, S, Coghill, D, Faraone, S V, Franke, B, Gleitz, M, Greven, C U, Kooij, S, Leffa, D T, Rommelse, N, Newcorn, J H, Polanczyk, G V, Rohde, L A, Simonoff, E, Stein, M, Vitiello, B, Yazgan, Y, Roesler, M, Doepfner, M & Banaschewski, T 2022, ' Toward Precision Medicine in ADHD ', Frontiers in Behavioral Neuroscience, vol. 16, 900981 . https://doi.org/10.3389/fnbeh.2022.900981
- Accession number :
- edsair.doi.dedup.....9fc5d8759338fab40b5713285ecb2bc0