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Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study
- Source :
- European journal of obstetrics, gynecology, and reproductive biology. 254
- Publication Year :
- 2020
-
Abstract
- Objective Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. Study design This retrospective cohort study was undertaken between January 1986 and February 2019, and the clinicopathological data of 4897 women with malignant ovarian tumours were collected. Seventy-seven patients with stage I sex cord-stromal tumours were eligible for inclusion. The characteristics and survival outcomes of these patients were examined. To investigate the prognostic effects of uterine-preserving surgery, baseline imbalances between patients with and without uterine-preserving surgery were adjusted using an inverse probability of treatment weighting with propensity scores composed of independent clinical variables. Results The mean ages of patients in the uterine-preserving surgery and non-uterine-preserving surgery groups were 39.8 and 57.8 years, respectively. After inverse probability of treatment weighting adjustments, no significant differences in overall survival (p = 0.205) or recurrence-free survival (p=0.071) were observed between the uterine-preserving surgery and non-uterine-preserving surgery groups. Estimated 10-year overall survival rates were 98.7 % in the uterine-preserving surgery group and 95.9 % in the non-uterine-preserving surgery group, and 10-year recurrence-free survival rates were 87.2 % in the uterine-preserving surgery group and 78.2 % in the non-uterine-preserving surgery group. Uterine-preserving surgery did not significantly affect the site of tumour recurrence. Conclusion Uterine-preserving surgery may be a feasible surgical option for patients with stage I sex cord-stromal tumours. Further research is needed to guarantee prognostic accuracy and develop effective therapeutic approaches for sex cord-stromal tumours.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
Stromal cell
Gonadal cord
medicine.medical_treatment
Ovary
Affect (psychology)
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Humans
Sex Cord-Gonadal Stromal Tumors
030212 general & internal medicine
Neoplasm Staging
Retrospective Studies
Ovarian Neoplasms
030219 obstetrics & reproductive medicine
Hysterectomy
business.industry
Inverse probability weighting
Obstetrics and Gynecology
Retrospective cohort study
Middle Aged
medicine.anatomical_structure
Reproductive Medicine
Propensity score matching
Female
Neoplasm Recurrence, Local
Stromal Cells
business
Subjects
Details
- ISSN :
- 18727654
- Volume :
- 254
- Database :
- OpenAIRE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Accession number :
- edsair.doi.dedup.....9fc412a9327dd6082aeefac69b5fd7fa