Back to Search
Start Over
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland
- Source :
- Nature Microbiology, da Silva Filipe, A, Shepherd, J G, Williams, T, Hughes, J, Aranday-Cortes, E, Asamaphan, P, Ashraf, S, Balcazar, C, Brunker, K, Campbell, A, Carmichael, S, Davis, C, Dewar, R, Gallagher, M D, Gunson, R, Hill, V, Ho, A, Jackson, B, James, E, Jesudason, N, Johnson, N, McWilliam Leitch, E C, Li, K, MacLean, A, Mair, D, McAllister, D A, McCrone, J T, McDonald, S E, McHugh, M P, Morris, A K, Nichols, J, Niebel, M, Nomikou, K, Orton, R J, O'Toole, Á, Palmarini, M, Parcell, B J, Parr, Y A, Rambaut, A, Rooke, S, Shaaban, S, Shah, R, Singer, J B, Smollett, K, Starinskij, I, Tong, L, Wastnedge, E, Holden, M T G, Robertson, D L & Templeton, K 2020, ' Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland ', Nature Microbiology, vol. 6, no. 1, pp. 112-122 . https://doi.org/10.1038/s41564-020-00838-z
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and epidemiological approach. Sequencing of 1,314 SARS-CoV-2 viral genomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotland on at least 283 occasions during February and March 2020. Epidemiological analysis confirmed that early introductions of SARS-CoV-2 originated from mainland Europe (the majority from Italy and Spain). We identified subsequent early outbreaks in the community, within healthcare facilities and at an international conference. Community transmission occurred after 2 March, 3 weeks before control measures were introduced. Earlier travel restrictions or quarantine measures, both locally and internationally, would have reduced the number of COVID-19 cases in Scotland. The risk of multiple reintroduction events in future waves of infection remains high in the absence of population immunity.
- Subjects :
- Adult
Male
Microbiology (medical)
medicine.medical_specialty
Viral epidemiology
Immunology
Genome, Viral
Applied Microbiology and Biotechnology
Microbiology
law.invention
Herd immunity
03 medical and health sciences
law
Intensive care
Epidemiology
Quarantine
medicine
Genetics
Humans
Author Correction
Phylogeny
030304 developmental biology
Aged
0303 health sciences
Molecular Epidemiology
Travel
Molecular epidemiology
030306 microbiology
Transmission (medicine)
SARS-CoV-2
Outbreak
COVID-19
High-Throughput Nucleotide Sequencing
Cell Biology
Middle Aged
C700
Europe
Geography
Spain
Mainland
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 20585276
- Database :
- OpenAIRE
- Journal :
- Nature Microbiology
- Accession number :
- edsair.doi.dedup.....9fc294a4a8227b8798d9ba182c92a96d
- Full Text :
- https://doi.org/10.1038/s41564-020-00838-z