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Enteroparasite and vivax malaria co-infection on the Brazil-French Guiana border: Epidemiological, haematological and immunological aspects
- Source :
- PLoS ONE, Vol 13, Iss 1, p e0189958 (2018), PLoS ONE, Repositório Digital do Instituto Evandro Chagas (Patuá), Instituto Evandro Chagas (IEC), instacron:IEC
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- Federal University of Para. Postgraduate Program in the Biology of Infectious and Parasitic Agents. Bel?m, PA, Brazil / Federal University of Amapa. Laboratory of morphofunctional and parasitic studies with impact on health. Macap?, AP, Brazil. Amap? State Secretary of Health. Amap? Central Laboratory. Macap?, AP, Brazil. Federal University of Amap? - Oiapoque Binational Campus. Oiapoque, AP, Brazil. Amap? State Secretary of Health. Amap? Central Laboratory. Macap?, AP, Brazil. Centre Hospitalier de Cayenne. Centre d?Investigation Clinique. Cayenne, French Guiana. Federal University of Para. Postgraduate Program in Neuroscience and Cell Biology. Bel?m, PA, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Fluminense Federal University. Niter?i, RJ, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Federal University of Para. Postgraduate Program in the Biology of Infectious and Parasitic Agents. Bel?m, PA, Brazil / Federal University of Para. Laboratory of Microbiology and Immunology. Bel?m, PA, Brazil. Federal University of Para. Postgraduate Program in the Biology of Infectious and Parasitic Agents. Bel?m, PA, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. / Fluminense Federal University, Nitero?i, Rio de Janeiro State, Brazil, Malaria-enteroparasitic co-infections are known for their endemicity. Although they are prevalent, little is known about their epidemiology and effect on the immune response. This study evaluated the effect of enteroparasite co-infections with malaria caused by Plasmodium vivax in a border area between Brazil and French Guiana. The cross sectional study took place in Oiapoque, a municipality of Amap?, on the Amazon border. Malaria was diagnosed using thick blood smears, haemoglobin dosage by an automated method and coproparasitology by the Hoffman and Faust methods. The anti-PvMSP-119 IgG antibodies in the plasma were evaluated using ELISA and Th1 (IFN-?, TNF-? and IL-2), and Th2 (IL-4, IL-5 and IL-10) cytokine counts were performed by flow cytometry. The participants were grouped into those that were monoinfected with vivax malaria (M), vivax malaria-enteroparasite co-infected (CI), monoinfected with enteroparasite (E) and endemic controls (EC), who were negative for both diseases. 441 individuals were included and grouped according to their infection status: [M 6.9% (30/441)], [Cl 26.5% (117/441)], [E 32.4% (143/441)] and [EC 34.2% (151/441)]. Males prevailed among the (M) 77% (23/30) and (CI) 60% (70/117) groups. There was a difference in haemoglobin levels among the different groups under study for [EC-E], [EC-Cl], [E-M] and [Cl-M], with (p < 0.01). Anaemia was expressed as a percentage between individuals [CI-EC (p < 0.05)]. In terms of parasitaemia, there were differences for the groups [CI-M (p < 0.05)]. Anti-PvMSP-119 antibodies were detected in 51.2% (226/441) of the population. The level of cytokines evaluation revealed a large variation in TNF-? and IL-10 concentrations in the co-infected group. In this study we did not observe any influence of coinfection on the acquisition of IgG antibodies against PvMSP119, as well as on the profile of the cytokines that characterize the Th1 and Th2 patterns. However, co-infection increased TNF-? and IL-10 levels.
- Subjects :
- 0301 basic medicine
Plasmodium
Cross-sectional study
Guiana Francesa / epidemiologia
Physiology
Mal?ria Vivax / complica??es
Plasmodium vivax
Protozoan Proteins
lcsh:Medicine
Citometria de Fluxo / m?todos
Mal?ria Vivax / sangue
Gastroenterology
Brasil / epidemiologia
0302 clinical medicine
Intestinal Parasites
Immune Physiology
Epidemiology
Medicine and Health Sciences
lcsh:Science
Protozoans
education.field_of_study
Prote?nas de Protozo?rios / imunologia
Innate Immune System
Multidisciplinary
biology
Mal?ria Vivax / epidemiologia
Malarial Parasites
Eukaryota
Flow Cytometry
French Guiana
Imunoglobulina G / imunologia
Infectious Diseases
Doen?as Parasit?rias / epidemiologia
Coinfection
Cytokines
Ensaio de Imunoadsor??o Enzim?tica / m?todos
Antibody
Estudos Transversais / m?todos
Brazil
Helmint?ase / parasitologia
Research Article
medicine.medical_specialty
Doen?as Parasit?rias / complica??es
030231 tropical medicine
Population
Immunology
Enzyme-Linked Immunosorbent Assay
03 medical and health sciences
Fezes / parasitologia
Internal medicine
Helminths
Parasite Groups
parasitic diseases
medicine
Parasitic Diseases
Malaria, Vivax
Animals
Humans
Citocinas / sangue
education
Doen?as Parasit?rias / sangue
business.industry
lcsh:R
Organisms
Biology and Life Sciences
Molecular Development
medicine.disease
biology.organism_classification
Tropical Diseases
Invertebrates
Parasitic Protozoans
Malaria
030104 developmental biology
Cross-Sectional Studies
Immune System
Co-Infections
Immunoglobulin G
Enteropatias Parasit?rias / epidemiologia
biology.protein
Parasitology
lcsh:Q
business
Coinfec??o / parasitologia
Parasitic Intestinal Diseases
Apicomplexa
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....9fb96c12b8d9be81db6e7e282c882ad8