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Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications
- Source :
- Biomolecules, Vol 11, Iss 254, p 254 (2021), Digital.CSIC. Repositorio Institucional del CSIC, instname, Biomolecules
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- © 2021 by the authors.<br />The dopaminergic system can adapt to the different physiological or pathological situations to which the kidneys are subjected throughout life, maintaining homeostasis of natriuresis, extracellular volume, and blood pressure levels. The role of renal dopamine receptor dysfunction is clearly established in the pathogenesis of essential hypertension. Its associations with other pathological states such as insulin resistance and redox balance have also been associated with dysfunction of the dopaminergic system. The different dopamine receptors (D1–D5) show a protective effect against hypertension and kidney disorders. It is essential to take into account the various interactions of the dopaminergic system with other elements, such as adrenergic receptors. The approach to therapeutic strategies for essential hypertension must go through the blocking of those elements that lead to renal vasoconstriction or the restoration of the normal functioning of dopamine receptors. D1-like receptors are fundamental in this role, and new therapeutic efforts should be directed to the restoration of their functioning in many patients. More studies will be needed to allow the development of drugs that can be targeted to renal dopamine receptors in the treatment of hypertension.
- Subjects :
- 0301 basic medicine
kidney
hypertension
Adrenergic receptor
Dopamine
lcsh:QR1-502
Blood Pressure
Review
030204 cardiovascular system & hematology
Essential hypertension
Kidney
Biochemistry
lcsh:Microbiology
Receptors, Dopamine
03 medical and health sciences
0302 clinical medicine
Hyperinsulinism
Diabetes Mellitus
medicine
Animals
Homeostasis
Humans
Receptor
Molecular Biology
business.industry
Dopaminergic
medicine.disease
Rats
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
Vasoconstriction
Dopamine receptor
Hypertension
Kidney Diseases
Kidney disorder
Essential Hypertension
dopamine
business
Neuroscience
Glomerular Filtration Rate
medicine.drug
Subjects
Details
- Language :
- English
- Volume :
- 11
- Issue :
- 254
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....9fb8a3104ce2ac9167bb857f792ebd9b