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Mesenteric Complications After Hypothermic Cardiopulmonary Bypass with Cardiac Arrest: Underlying Mechanisms
- Source :
- Artificial Organs. 26:943-946
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- The aim of this study was to determine the pathophysiological mechanisms of postcardiopulmonary bypass (CPB) intestinal dysfunction using an in vivo canine model of extracorporeal circulation. Six dogs underwent a 90 min hypothermic CPB with continuous monitoring of mean arterial blood pressure (MAP) and mesenteric blood flow (MBF). Reactive hyperemia and vasodilator responses of the superior mesenteric artery to acetylcholine and sodium nitroprusside were determined before and after CPB. Mesenteric lactate production, glucose consumption, creatine kinase (CK) release and venous free radicals were determined. CPB induced a significant fall (p < 0.05) in MAP and MBF. After CPB, reactive hyperemia (-26 +/- 15% versus -53 +/- 2%, p < 0.05) and the response to acetylcholine (-42 +/- 9 versus -55 +/- 6%, p < 0.05) were significantly decreased. Reperfusion increased lactate production (0.8 +/- 0.09 mmol/L versus 0.4 +/- 0.18, p < 0.05) and the CK release (446 +/- 98 U/L versus 5 +/- 19 U/L, p < 0.01). Endothelial dysfunction, conversion from aerobic to anaerobic metabolism, and intestinal cell necrosis seem to be responsible for intestinal complications associated with CPB.
- Subjects :
- medicine.medical_specialty
Time Factors
Biomedical Engineering
Medicine (miscellaneous)
Blood Pressure
Bioengineering
Peritoneal Diseases
law.invention
Biomaterials
Dogs
Hypothermia, Induced
law
medicine.artery
Internal medicine
medicine
Cardiopulmonary bypass
Animals
Mesentery
Splanchnic Circulation
Superior mesenteric artery
Endothelial dysfunction
Reactive hyperemia
Cardiopulmonary Bypass
biology
business.industry
Extracorporeal circulation
General Medicine
medicine.disease
Heart Arrest
Vasodilation
Disease Models, Animal
Oxidative Stress
surgical procedures, operative
medicine.anatomical_structure
Anesthesia
Cardiology
biology.protein
Vascular resistance
Vascular Resistance
Creatine kinase
Sodium nitroprusside
business
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 15251594 and 0160564X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Artificial Organs
- Accession number :
- edsair.doi.dedup.....9fb144686c43499c433a1cb6d0f503ad