Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

Authors :: A. M. M. Eggermont
J.H.W. de Wilt
G. De Boeck
E. A. de Bruijn
S T van Tiel
Timo L.M. ten Hagen
Surgery
Cardiothoracic Surgery
Source :: British Journal of Cancer, The British journal of cancer, British Journal of Cancer, 82(5), 1000-1003. Nature Publishing Group
Publication Year :: 2000
Abstract: Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP. (C) 2000 Cancer Research Campaign.

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