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Family-based association study of the arsenite methyltransferase gene (AS3MT, rs11191454) in Korean children with attention-deficit hyperactivity disorder
- Source :
- Psychiatric Genetics. 25:26-30
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- We examined the association between the selected polymorphisms in two candidate genes, the arsenite methyltransferase gene (AS3MT, rs11191454) and the inter-α-trypsin inhibitors heavy chain-3 gene (ITIH3, rs2535629), and attention-deficit hyperactivity disorder (ADHD) in a Korean population. A total of 238 patients with ADHD, along with both of their biological parents, were recruited. The children were administered intelligence quotient tests, whereas their parents completed the Child Behavior Checklist. In the transmission disequilibrium test on 181 trios, we found overtransmission of the A allele at the AS3MT rs11191454 polymorphism in children with ADHD (χ²=8.81, P=0.003). However, there was no preferential transmission at the ITIH3 rs52535629 polymorphism (χ²=0.14, P=0.707). Our results provide preliminary evidence for the overtransmission of the A allele at the AS3MT rs11191454 polymorphism in ADHD.
- Subjects :
- Male
Linkage disequilibrium
Candidate gene
Adolescent
Genotype
Child Behavior
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Asian People
Polymorphism (computer science)
Alpha-Globulins
Arsenic Poisoning
mental disorders
Genetics
medicine
Humans
Attention deficit hyperactivity disorder
Genetic Predisposition to Disease
Arsenite methyltransferase
Allele
Child
Child Behavior Checklist
Biological Psychiatry
Genetics (clinical)
Intelligence Tests
business.industry
Methyltransferases
Transmission disequilibrium test
medicine.disease
Psychiatry and Mental health
Attention Deficit Disorder with Hyperactivity
Linear Models
Female
business
Subjects
Details
- ISSN :
- 09558829
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Psychiatric Genetics
- Accession number :
- edsair.doi.dedup.....9f931f34daf372f8e179700a6bf9bfa3
- Full Text :
- https://doi.org/10.1097/ypg.0000000000000064