Back to Search Start Over

Family-based association study of the arsenite methyltransferase gene (AS3MT, rs11191454) in Korean children with attention-deficit hyperactivity disorder

Authors :
Soo Churl Cho
Jae Hoon Cheong
Jae-Won Kim
Hee Jeong Yoo
Subin Park
Min-Sup Shin
Boong Nyun Kim
Jong-Eun Park
Doug Hyun Han
Source :
Psychiatric Genetics. 25:26-30
Publication Year :
2015
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2015.

Abstract

We examined the association between the selected polymorphisms in two candidate genes, the arsenite methyltransferase gene (AS3MT, rs11191454) and the inter-α-trypsin inhibitors heavy chain-3 gene (ITIH3, rs2535629), and attention-deficit hyperactivity disorder (ADHD) in a Korean population. A total of 238 patients with ADHD, along with both of their biological parents, were recruited. The children were administered intelligence quotient tests, whereas their parents completed the Child Behavior Checklist. In the transmission disequilibrium test on 181 trios, we found overtransmission of the A allele at the AS3MT rs11191454 polymorphism in children with ADHD (χ²=8.81, P=0.003). However, there was no preferential transmission at the ITIH3 rs52535629 polymorphism (χ²=0.14, P=0.707). Our results provide preliminary evidence for the overtransmission of the A allele at the AS3MT rs11191454 polymorphism in ADHD.

Details

ISSN :
09558829
Volume :
25
Database :
OpenAIRE
Journal :
Psychiatric Genetics
Accession number :
edsair.doi.dedup.....9f931f34daf372f8e179700a6bf9bfa3
Full Text :
https://doi.org/10.1097/ypg.0000000000000064