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Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A
- Source :
- Journal of Asian natural products research. 12(7)
- Publication Year :
- 2010
-
Abstract
- Eighteen schizandrin A derivatives, possessing an acyl group at 7-OH and/or halogen(s) at C-4 and C-11, were designed and synthesized for evaluation of their in vitro ability to inhibit multidrug resistance (MDR). They exhibit weak ability to restore the intracellular Rhodamine 123 in human hepatocarcinoma MDR cell lines Bel7402 and HCT8 relative to the reference drug verapamil.
- Subjects :
- Pharmaceutical Science
Drug resistance
Pharmacology
Rhodamine 123
Lignans
Analytical Chemistry
chemistry.chemical_compound
Cyclooctanes
Structure-Activity Relationship
Drug Discovery
Structure–activity relationship
Humans
Polycyclic Compounds
P-glycoprotein
Schisandra
biology
Molecular Structure
Chemistry
Organic Chemistry
Biological activity
General Medicine
In vitro
Drug Resistance, Multiple
Multiple drug resistance
Complementary and alternative medicine
Biochemistry
biology.protein
Molecular Medicine
Intracellular
Subjects
Details
- ISSN :
- 14772213
- Volume :
- 12
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Asian natural products research
- Accession number :
- edsair.doi.dedup.....9f8bdb0575c8164ef644fd4f7bc97e35