Back to Search
Start Over
Beneficial Effect of Herbal Formulation KM1608 on Inflammatory Bowl Diseases: A Preliminary Experimental Study
- Source :
- Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules, Vol 23, Iss 8, p 2068 (2018), Molecules, Volume 23, Issue 8
- Publication Year :
- 2018
-
Abstract
- Aucklandia lappa DC., Terminalia chebula Retz and Zingiber officinale Roscoe have been traditionally used in east Asia to treat chronic diarrhea and abdominal pain. This study aimed to evaluated the anti-inflammatory activity of KM1608, which is composed of three natural herbs in a mouse model of dextran sodium sulfate (DSS)-induced ulcerative colitis. The anti-inflammatory activity and underlying mechanism were assessed in vitro using LPS-treated RAW264.7 cells. The in vivo effect of KM1608 on DSS-induced colitis was examined after oral administration in mice. KM1608 significantly inhibited the inflammatory mediators such as nitric oxide, interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor (TNF)-&alpha<br />in LPS-treated RAW264.7 cells. The inhibitory effect of KM1608 was attributed to the reduction of Akt phosphorylation in the LPS-treated cells. In the mouse model, oral administration of KM1608 significantly improved DSS-induced colitis symptoms, such as disease activity index (DAI), colon length, and colon weight, as well as suppressed the expression of IL-6, TNF-&alpha<br />and myeloperoxidase (MPO) in the DSS-induced colitis tissues. Taken together, KM1608 improved colitis through the regulation of inflammatory responses, suggesting that KM1608 has potential therapeutic use in the treatment of inflammatory diseases.
- Subjects :
- Terminalia chebula Retz
Phytochemicals
Anti-Inflammatory Agents
Pharmaceutical Science
Pharmacology
030226 pharmacology & pharmacy
01 natural sciences
Analytical Chemistry
Mice
0302 clinical medicine
Drug Discovery
Phosphorylation
Chromatography, High Pressure Liquid
anti-inflammatory
biology
Dextran Sulfate
Interleukin
Aucklandia lappa DC
Colitis
Ulcerative colitis
Terminalia chebula
Chemistry (miscellaneous)
Myeloperoxidase
Molecular Medicine
Cytokines
Tumor necrosis factor alpha
medicine.symptom
Inflammation Mediators
Oxidation-Reduction
medicine.drug_class
Inflammation
Anti-inflammatory
Article
Zingiber officinale Roscoe
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
medicine
Animals
Physical and Theoretical Chemistry
ulcerative colitis
010405 organic chemistry
business.industry
Plant Extracts
Organic Chemistry
medicine.disease
Inflammatory Bowel Diseases
0104 chemical sciences
Disease Models, Animal
RAW 264.7 Cells
biology.protein
business
Proto-Oncogene Proteins c-akt
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 23
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....9f89ab50cd75bac98870e5e74a4dbd89