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Impaired exercise capacity following atrial septal defect closure: an invasive study of the right heart and pulmonary circulation
- Source :
- Pulmonary circulation. 4(4)
- Publication Year :
- 2014
-
Abstract
- Patients with early repair of an isolated atrial septal defect (ASD) are expected to have unremarkable right ventricular (RV) and pulmonary circulation physiology. Some studies, however, suggest persistent functional impairment. We aimed to examine the role of abnormal RV and pulmonary vascular response to exercise in patients who had undergone ASD closure. Using a previously published data set, we reviewed invasive exercise cardiopulmonary testing with right-sided hemodynamic data for 12 asymptomatic patients who had undergone ASD closure. The 5 (42%) patients with impaired maximal oxygen uptake ([Formula: see text]) were older and exhibited a lower peak cardiac index (5.6 ± 0.8 vs. 9.0 ± 1.2 L/min/m(2); P = .005) because of abnormal stroke volume augmentation (+3.2 ± 3.9 vs. +17.4 ± 10.2 mL/m(2); P = .02). While all resting hemodynamic variables were similar, patients with low [Formula: see text] tended to have abnormal total pulmonary vascular resistance change during exercise (+11% ± 41% vs. -28% ± 26%; P = .06) and had a steeper relation between mean pulmonary arterial pressure and cardiac index (5.8 ± 0.6 vs. 2.2 ± 0.1 L/min/m(2); P = .02). The increase in peak mean RV power during exercise was also significantly lower in the impaired-[Formula: see text] patients (4.7 ± 1.6 vs. 7.6 ± 2.1 J/s; P = .04). As described in the original study, despite normal resting hemodynamics, a subset of asymptomatic patients with repaired ASD had diminished exercise capacity. Our analysis allows us to conclude that this is due to a combination of abnormal pulmonary vascular response to exercise and impaired RV function.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
business.industry
Cardiac index
Hemodynamics
VO2 max
Stroke volume
Exercise capacity
Asymptomatic
medicine.anatomical_structure
Internal medicine
Right heart
Vascular resistance
Cardiology
Medicine
medicine.symptom
business
Original Research
Subjects
Details
- ISSN :
- 20458932
- Volume :
- 4
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pulmonary circulation
- Accession number :
- edsair.doi.dedup.....9f83fe0bb47c08c38eceea8db66c6279