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Cannabis-Associated Psychotic-like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus
- Source :
- Journal of the American Academy of Child and Adolescent Psychiatry, Journal of the American Academy of Child and Adolescent Psychiatry, 2020, 59 (5), pp.642-649. ⟨10.1016/j.jaac.2019.05.034⟩, Journal of the American Academy of Child and Adolescent Psychiatry, Elsevier, 2020, 59 (5), pp.642-649. ⟨10.1016/j.jaac.2019.05.034⟩, Journal of the American Academy of Child and Adolescent Psychiatry, Elsevier, In press, ⟨10.1016/j.jaac.2019.05.034⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Objective: Cannabis consumption during adolescence has been reported as a risk factor for psychotic-like experiences (PLEs) and schizophrenia. However, brain developmental processes associated with cannabis-related PLEs are still poorly described.Method: A total of 706 adolescents from the general population who were recruited by the IMAGEN consortium had structural magnetic resonance imaging scans at both 14 and 19 years of age. We used deformation-based morphometry to map voxelwise brain changes between the two time points, using the pairwise algorithm in SPM12b. We used an a priori region-of-interest approach focusing on the hippocampus/parahippocampus to perform voxelwise linear regressions. Lifetime cannabis consumption was assessed using the European School Survey Project on Alcohol and other Drugs (ESPAD), and PLEs were assessed with the Comprehensive Assessment Psychotic-like experiences (CAPE) tool. We first tested whether hippocampus/parahippocampus development was associated with PLEs. Then we formulated and tested an a priori simple mediation model in which uncus development mediates the association between lifetime cannabis consumption and PLEs.Results: We found that PLEs were associated with reduced expansion within a specific region of the right hippocampus/parahippocampus formation, the uncus (p = .002 at the cluster level, p = .018 at the peak level). The partial simple mediation model revealed a significant total effect from lifetime cannabis consumption to PLEs (b = 0.069, 95% CI = 0.04−0.1, p =2 × 10−16), as well as a small yet significant, indirect effect of right uncus development (0.004; 95% CI = 0.0004−0.01, p = .026).Conclusion: We show here that the uncus development is involved in the cerebral basis of PLEs in a population-based sample of healthy adolescents
- Subjects :
- cannabis
Mediation (statistics)
Marijuana Abuse
psychotic-like experiences (PLEs)
Adolescent
Population
Hippocampus
deformation-based morphometry
uncus
Risk Factors
Surveys and Questionnaires
Developmental and Educational Psychology
medicine
Humans
0501 psychology and cognitive sciences
paired designed MRI
Risk factor
education
education.field_of_study
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
biology
business.industry
05 social sciences
medicine.disease
biology.organism_classification
Uncus
Psychiatry and Mental health
medicine.anatomical_structure
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
Psychotic Disorders
Schizophrenia
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Parahippocampal Gyrus
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Cannabis
business
Parahippocampal gyrus
050104 developmental & child psychology
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 08908567
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Child and Adolescent Psychiatry, Journal of the American Academy of Child and Adolescent Psychiatry, 2020, 59 (5), pp.642-649. ⟨10.1016/j.jaac.2019.05.034⟩, Journal of the American Academy of Child and Adolescent Psychiatry, Elsevier, 2020, 59 (5), pp.642-649. ⟨10.1016/j.jaac.2019.05.034⟩, Journal of the American Academy of Child and Adolescent Psychiatry, Elsevier, In press, ⟨10.1016/j.jaac.2019.05.034⟩
- Accession number :
- edsair.doi.dedup.....9f81a33a41f265ff30904efb6a1a5185