Supplementary Figure 5 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss

PDF - 1578 KB, BEZ235 functions as mTOR inhibitor, without evidence of PI3K inhibition, and induces invasive protrusions in MCF10A cultures. (A) BEZ235 inhibits mTORC1/mTORC2 without inhibition of PI3K in MCF10A acini.