Back to Search
Start Over
The debatable presence of PIWI‐interacting RNAs in invasive breast cancer
The debatable presence of PIWI‐interacting RNAs in invasive breast cancer
- Source :
- Cancer Medicine, Vol 10, Iss 11, Pp 3593-3603 (2021), Cancer Medicine
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Numerous factors influence breast cancer (BC) prognosis, thus complicating the prediction of outcome. By identifying biomarkers that would distinguish the cases with poorer response to therapy already at the time of diagnosis, the rate of survival could be improved. Lately, Piwi‐interacting RNAs (piRNAs) have been introduced as potential cancer biomarkers, however, due to the recently raised challenges in piRNA annotations, further evaluation of piRNAs’ involvement in cancer is required. We performed small RNA sequencing in 227 fresh‐frozen breast tissue samples from the Eastern Finnish Kuopio Breast Cancer Project material to study the presence of piRNAs in BC and their associations with the clinicopathological features and outcome of BC patients. We observed the presence of three small RNAs annotated as piRNA database entries (DQ596932, DQ570994, and DQ571955) in our samples. The actual species of these RNAs however remain uncertain. All three small RNAs were upregulated in grade III tumors and DQ596932 additionally in estrogen receptor negative tumors. Furthermore, patients with estrogen receptor positive BC and higher DQ571955 had shorter relapse‐free survival and poorer BC‐specific survival, thus indicating DQ571955 as a candidate predictive marker for radiotherapy response in estrogen receptor positive BC. DQ596932 showed possible prognostic value in BC, whereas DQ570994 was identified as a candidate predictive marker for tamoxifen and chemotherapy response. These three small RNAs appear as candidate biomarkers for BC, which could after further investigation provide novel approaches for the treatment of therapy resistant BC. Overall, our results indicate that the prevalence of piRNAs in cancer is most likely not as comprehensive as has been previously thought.<br />We have observed three small RNAs associating with clinical characteristics and patient outcome in breast cancer. The actual species of these RNAs needs further clarification but these results indicate that the dysregulation of piRNAs in cancer is most likely not as general a phenomenon as has been previously thought.
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_treatment
Estrogen receptor
Piwi-interacting RNA
Antineoplastic Agents
Breast Neoplasms
Biology
Disease-Free Survival
03 medical and health sciences
transcriptomics
0302 clinical medicine
Breast cancer
breast cancer
medicine
Biomarkers, Tumor
Humans
Radiology, Nuclear Medicine and imaging
Breast
RNA, Small Interfering
prognostic factor
RC254-282
Original Research
next generation sequencing
Predictive marker
Radiotherapy
Sequence Analysis, RNA
Cancer
Clinical Cancer Research
biomarkers
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Prognosis
Up-Regulation
Radiation therapy
Tamoxifen
030104 developmental biology
Treatment Outcome
Oncology
Receptors, Estrogen
030220 oncology & carcinogenesis
Cancer research
non‐coding RNAs
Cancer biomarkers
Female
Neoplasm Grading
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 10
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....9f6bd1c2b39979bf2ad2ad9e013aa644