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Histamine in cancer immunology and immunotherapy. Current status and new perspectives
- Source :
- Pharmacology research & perspectives Vol.9, No.5, 2021, Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021), British Journal of Pharmacology. 2021, 9 (5), Pharmacology Research & Perspectives, Repositorio Institucional (UCA), Pontificia Universidad Católica Argentina, instacron:UCA
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in a fraction of patients. Thus, understanding the characteristics and profiles of immune cells in the tumor microenvironment (TME) is a necessary step to move forward in the design of new immunomodulatory strategies that can boost the immune system to fight cancer. Histamine produces a complex and fine‐tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory responses of the innate and adaptive immunity. Considering the important actions of histamine‐producing immune cells in the TME, in this review we first address the most important immunomodulatory roles of histamine and histamine receptors in the context of cancer development and progression. In addition, this review highlights the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting histamine receptors.<br />Targeting the histaminergic system represents a promising strategy for the potential therapeutic exploitation of new immunomodulatory drugs that can boost the immune system to fight cancer.
- Subjects :
- Neutrophils
T-Lymphocytes
medicine.medical_treatment
chemistry.chemical_compound
Histamine receptor
Antineoplastic Agents, Immunological
Cancer immunotherapy
Neoplasms
Tumor Microenvironment
CANCER DE MAMA
Medicine
Invited Reviews
Mast Cells
General Pharmacology, Toxicology and Pharmaceutics
innate immunity
Research Highlights from South America
Cancer immunology
B-Lymphocytes
INMUNIDAD ANTITUMORAL
leukemia
adaptive immunity
Acquired immune system
Basophils
Killer Cells, Natural
Neurology
Receptors, Histamine
immunotherapy
INMUNOTERAPIA
Histamine
anti‐tumor immunity
RECEPTORES DE HISTAMINA
RM1-950
Lymphocytes, Tumor-Infiltrating
breast cancer
Immune system
Humans
Invited Review
Innate immune system
business.industry
Macrophages
LEUCEMIA
INMUNIDAD ADAPTATIVA
Immunotherapy
Immunity, Innate
chemistry
histamine receptors
Immunology
Therapeutics. Pharmacology
business
INMUNIDAD INNATA
Subjects
Details
- ISSN :
- 20521707
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Pharmacology Research & Perspectives
- Accession number :
- edsair.doi.dedup.....9f652c53f0723599fa1f4af9e4861187