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Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
- Source :
- Cell Reports, Vol 37, Iss 7, Pp 110006-(2021)
- Publication Year :
- 2020
-
Abstract
- Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
- Subjects :
- IgM
QH301-705.5
reverse transcytosis
chemical and pharmacologic phenomena
General Biochemistry, Genetics and Molecular Biology
Mice
Peyer's Patches
Immune system
Antigen
microfold cell
Animals
Biology (General)
Intestinal Mucosa
Immunity, Mucosal
Microfold cell
Mice, Inbred BALB C
biology
Chemistry
TOSO/FAIM3
food and beverages
Membrane Proteins
Apical membrane
Cell biology
Intestines
Lymphatic system
Immunization
Transcytosis
Immunoglobulin M
Immunoglobulin A, Secretory
biology.protein
Female
Antibody
Apoptosis Regulatory Proteins
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 37
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Cell reports
- Accession number :
- edsair.doi.dedup.....9f64eb824e1e2d19f1662d87dd2f585a