Experimental Ultraviolet Light Carcinogenesis

Understanding the relationships between chemical and ultraviolet light (UVL) cancer formation has been clouded by the influence of light energy on the carcinogen and/or the substrate (1—5). Recent studies indicate that under appropriate conditions, carcinogenic and sub-carcinogenic amounts of UVL will stimulate cancer formation initiated by a single appheation of the chemical carcinogen 7, 12-dimethyl benz (a) anthracene (6—8). The resultant responses simulate the pattern described for carcinogenic summation (9, 10). In the present study we further examined the influence of chemical stimulation on UVL carcinogenesis