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Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts:A Harmonization Study in the Mechanisms of the Development of Allergy Project

Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts:A Harmonization Study in the Mechanisms of the Development of Allergy Project

Authors :
Eva Hallner
Marta Benet
Mariona Pinart
Stefano Guerra
Jacopo Lenzi
Isabella Annesi-Maesano
Manolis Kogevinas
Lourdes Cirugeda
Richard Albang
Esben Eller
Karin C. Lødrup Carlsen
Jordi Sunyer
Maties Torrent
Davide Gori
Maria Pia Fantini
Beatrix Gerhard
Kai-Håkon Carlsen
Rosemary R. C. McEachan
Thomas Keil
Emily S. Petherick
Isabelle Momas
Marie Standl
Cynthia Hohmann
Dieter Maier
Alet H. Wijga
Inger Kull
John Wright
Daniela Porta
Josep M. Antó
Ulrike Gehring
Christina Tischer
Jean Bousquet
Nour Baïz
Judith Garcia-Aymerich
Eleonora Minina
Fanny Rancière
Carsten Bindslev-Jensen
Silvia Narduzzi
Benet, Marta
Albang, Richard
Pinart, Mariona
Hohmann, Cynthia
Tischer, Christina G
Annesi-Maesano, Isabella
Baïz, Nour
Bindslev-Jensen, Carsten
Lødrup Carlsen, Karin C
Carlsen, Kai-Hakon
Cirugeda, Lourde
Eller, Esben
Fantini, Maria Pia
Gehring, Ulrike
Gerhard, Beatrix
Gori, Davide
Hallner, Eva
Kull, Inger
Lenzi, Jacopo
McEachan, Rosemary
Minina, Eleonora
Momas, Isabelle
Narduzzi, Silvia
Petherick, Emily S
Porta, Daniela
Rancière, Fanny
Standl, Marie
Torrent, Matie
Wijga, Alet H
Wright, John
Kogevinas, Manoli
Guerra, Stefano
Sunyer, Jordi
Keil, Thoma
Bousquet, Jean
Maier, Dieter
Anto, Josep M
Garcia-Aymerich, Judith
Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal)
Universitat Pompeu Fabra [Barcelona] (UPF)
Biomax Informatics [Planegg]
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)
Institut National de la Santé et de la Recherche Médicale (INSERM)
Université Pierre et Marie Curie - Paris 6 (UPMC)
University of Oslo (UiO)
Oslo University Hospital [Oslo]
Alma Mater Studiorum University of Bologna (UNIBO)
Utrecht University [Utrecht]
Karolinska Institutet [Stockholm]
Stockholm County Council
Université Sorbonne Paris Cité (USPC)
Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064)
Université Paris Descartes - Paris 5 (UPD5)
Direction de l'Action Sociale de l'Enfance et de la Santé (DASES)
Mairie de Paris
Loughborough University
National Institute for Public Health and the Environment [Bilthoven] (RIVM)
University of Arizona
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Source :
Benet, M, Albang, R, Pinart, M, Hohmann, C, Tischer, C G, Annesi-Maesano, I, Baïz, N, Bindslev-Jensen, C, Lødrup Carlsen, K C, Carlsen, K-H, Cirugeda, L, Eller, E, Fantini, M P, Gehring, U, Gerhard, B, Gori, D, Hallner, E, Kull, I, Lenzi, J, McEachan, R, Minina, E, Momas, I, Narduzzi, S, Petherick, E S, Porta, D, Rancière, F, Standl, M, Torrent, M, Wijga, A H, Wright, J, Kogevinas, M, Guerra, S, Sunyer, J, Keil, T, Bousquet, J, Maier, D, Anto, J M & Garcia-Aymerich, J 2019, ' Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project ', American Journal of Epidemiology, vol. 188, no. 2, pp. 408–417 . https://doi.org/10.1093/aje/kwy242, Am. J. Epidemiol. 188, 408-417 (2019), American Journal of Epidemiology, American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (2), pp.408-417. ⟨10.1093/aje/kwy242⟩
Publication Year :
2019

Abstract

International audience; The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.

Details

Language :
English
ISSN :
00029262 and 14766256
Database :
OpenAIRE
Journal :
Benet, M, Albang, R, Pinart, M, Hohmann, C, Tischer, C G, Annesi-Maesano, I, Baïz, N, Bindslev-Jensen, C, Lødrup Carlsen, K C, Carlsen, K-H, Cirugeda, L, Eller, E, Fantini, M P, Gehring, U, Gerhard, B, Gori, D, Hallner, E, Kull, I, Lenzi, J, McEachan, R, Minina, E, Momas, I, Narduzzi, S, Petherick, E S, Porta, D, Rancière, F, Standl, M, Torrent, M, Wijga, A H, Wright, J, Kogevinas, M, Guerra, S, Sunyer, J, Keil, T, Bousquet, J, Maier, D, Anto, J M & Garcia-Aymerich, J 2019, ' Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project ', American Journal of Epidemiology, vol. 188, no. 2, pp. 408–417 . https://doi.org/10.1093/aje/kwy242, Am. J. Epidemiol. 188, 408-417 (2019), American Journal of Epidemiology, American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (2), pp.408-417. ⟨10.1093/aje/kwy242⟩
Accession number :
edsair.doi.dedup.....9f585ffa8de11f78a4a0fc45dee415b4
Full Text :
https://doi.org/10.1093/aje/kwy242