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Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts:A Harmonization Study in the Mechanisms of the Development of Allergy Project
Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts:A Harmonization Study in the Mechanisms of the Development of Allergy Project
- Source :
- Benet, M, Albang, R, Pinart, M, Hohmann, C, Tischer, C G, Annesi-Maesano, I, Baïz, N, Bindslev-Jensen, C, Lødrup Carlsen, K C, Carlsen, K-H, Cirugeda, L, Eller, E, Fantini, M P, Gehring, U, Gerhard, B, Gori, D, Hallner, E, Kull, I, Lenzi, J, McEachan, R, Minina, E, Momas, I, Narduzzi, S, Petherick, E S, Porta, D, Rancière, F, Standl, M, Torrent, M, Wijga, A H, Wright, J, Kogevinas, M, Guerra, S, Sunyer, J, Keil, T, Bousquet, J, Maier, D, Anto, J M & Garcia-Aymerich, J 2019, ' Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project ', American Journal of Epidemiology, vol. 188, no. 2, pp. 408–417 . https://doi.org/10.1093/aje/kwy242, Am. J. Epidemiol. 188, 408-417 (2019), American Journal of Epidemiology, American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (2), pp.408-417. ⟨10.1093/aje/kwy242⟩
- Publication Year :
- 2019
-
Abstract
- International audience; The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.
- Subjects :
- Male
medicine.medical_specialty
Epidemiology
data sharing
Pooling
MEDLINE
Harmonization
Allergy
Asthma
Birth Cohorts
Data Accuracy
Data Harmonization
Data Pooling
Data Sharing
data harmonization
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Hypersensitivity
Humans
030212 general & internal medicine
Child
birth cohorts
Comparability
Infant, Newborn
Infant
asthma
allergy
allergy, asthma, birth cohorts, data accuracy, data harmonization, data pooling, data sharing
3. Good health
Data sharing
Europe
Research Design
030220 oncology & carcinogenesis
Family medicine
Child, Preschool
data pooling
Cohort
data accuracy
Female
Psychology
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 00029262 and 14766256
- Database :
- OpenAIRE
- Journal :
- Benet, M, Albang, R, Pinart, M, Hohmann, C, Tischer, C G, Annesi-Maesano, I, Baïz, N, Bindslev-Jensen, C, Lødrup Carlsen, K C, Carlsen, K-H, Cirugeda, L, Eller, E, Fantini, M P, Gehring, U, Gerhard, B, Gori, D, Hallner, E, Kull, I, Lenzi, J, McEachan, R, Minina, E, Momas, I, Narduzzi, S, Petherick, E S, Porta, D, Rancière, F, Standl, M, Torrent, M, Wijga, A H, Wright, J, Kogevinas, M, Guerra, S, Sunyer, J, Keil, T, Bousquet, J, Maier, D, Anto, J M & Garcia-Aymerich, J 2019, ' Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project ', American Journal of Epidemiology, vol. 188, no. 2, pp. 408–417 . https://doi.org/10.1093/aje/kwy242, Am. J. Epidemiol. 188, 408-417 (2019), American Journal of Epidemiology, American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (2), pp.408-417. ⟨10.1093/aje/kwy242⟩
- Accession number :
- edsair.doi.dedup.....9f585ffa8de11f78a4a0fc45dee415b4
- Full Text :
- https://doi.org/10.1093/aje/kwy242