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Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus
- Source :
- Journal of General Virology. 96:2104-2113
- Publication Year :
- 2015
- Publisher :
- Microbiology Society, 2015.
-
Abstract
- Human metapneumovirus (hMPV) is a common cause of respiratory tract infection in the paediatrics population. Recently, we and others have shown that retinoic acid-inducible gene 1 (RIG-I)-like receptors (RLRs) are essential for hMPV-induced cellular antiviral signalling. However, the contribution of those receptors to host immunity against pulmonary hMPV infection is largely unexplored. In this study, mice deficient in mitochondrial antiviral-signalling protein (MAVS), an adaptor of RLRs, were used to investigate the role(s) of these receptors in pulmonary immune responses to hMPV infection. MAVS deletion significantly impaired the induction of antiviral and pro-inflammatory cytokines and the recruitment of immune cells to the bronchoalveolar lavage fluid by hMPV. Compared with WT mice, mice lacking MAVS demonstrated decreased abilities to activate pulmonary dendritic cells (DCs) and abnormal primary T-cell responses to hMPV infection. In addition, mice deficient in MAVS had a higher peak of viral load at day 5 post-infection (p.i.) than WT mice, but were able to clear hMPV by day 7 p.i. similarly to WT mice. Taken together, our data indicate a role of MAVS-mediated pathways in the pulmonary immune responses to hMPV infection and the early control of hMPV replication.
- Subjects :
- Male
T-Lymphocytes
viruses
Population
Mice
Immune system
Human metapneumovirus
Immunity
Virology
Animals
Humans
Metapneumovirus
Receptor
education
Lung
Adaptor Proteins, Signal Transducing
Mice, Knockout
education.field_of_study
Paramyxoviridae Infections
biology
virus diseases
Signal transducing adaptor protein
Dendritic Cells
biology.organism_classification
Immunity, Innate
Standard
respiratory tract diseases
Immunology
Cytokines
Female
Viral load
Subjects
Details
- ISSN :
- 14652099 and 00221317
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology
- Accession number :
- edsair.doi.dedup.....9f570fa03bb33ae799548eeaa5fd5f66