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Disrupted orbitomedial prefrontal limbic network in individuals with later-life depression
- Source :
- Journal of Affective Disorders. 204:112-119
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background Depression in old age is an increasing contributor to poor health and accompanying health care costs. Although there is an abundance of literature on later-life depression (LLD), the neural correlates have not been clarified. The aim of this study was to determine whether patients with LLD show abnormal gray matter volume (GMV) and white matter integrity by using multiple image analysis methods. Methods The study included 45 patients with LLD and 61 healthy participants who were matched for age, sex, years of education, and vascular risk factors. GMV was examined using voxel-based morphometry, while the white matter integrity was determined by tract-based spatial statistics and tract-specific analysis, which were obtained from high-resolution magnetic resonance images. Results Patients with LLD showed significantly less GMV in the orbitofrontal cortex, anterior cingulate, insula, amygdala, and temporal regions, as well as higher fractional anisotropy in the uncinate fasciculus, compared with healthy participants. Patients with LLD who had reduced orbitofrontal and insular GMV had more severe clinical variables. The reduced orbitofrontal GMV was associated with higher fractional anisotropy in the uncinate fasciculus. Limitation The effects of medication should also be considered when interpreting the results of this study. Conclusion Our results suggest that regional GMV is linked to white matter integrity of the uncinate fasciculus in the orbitomedial prefrontal limbic network, and the disruption of this network may be involved in the pathophysiology of LLD.
- Subjects :
- Male
medicine.medical_specialty
Prefrontal Cortex
Uncinate fasciculus
Audiology
Gyrus Cinguli
White matter
03 medical and health sciences
0302 clinical medicine
Fractional anisotropy
medicine
Humans
Gray Matter
Prefrontal cortex
Psychiatry
Aged
Depressive Disorder
Depression
Voxel-based morphometry
Amygdala
White Matter
030227 psychiatry
Psychiatry and Mental health
Clinical Psychology
Diffusion Tensor Imaging
medicine.anatomical_structure
Case-Control Studies
Female
Orbitofrontal cortex
Psychology
Insula
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 204
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....9f4e441022bfbec642ade156ddab5829