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Altered task-based and resting-state amygdala functional connectivity following real-time fMRI amygdala neurofeedback training in major depressive disorder
- Source :
- NeuroImage: Clinical, Vol 17, Iss, Pp 691-703 (2018), NeuroImage : Clinical
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Background We have previously shown that in participants with major depressive disorder (MDD) trained to upregulate their amygdala hemodynamic response during positive autobiographical memory (AM) recall with real-time fMRI neurofeedback (rtfMRI-nf) training, depressive symptoms diminish. Here, we assessed the effect of rtfMRI-nf on amygdala functional connectivity during both positive AM recall and rest. Method The current manuscript consists of a secondary analysis on data from our published clinical trial of neurofeedback. Patients with MDD completed two rtfMRI-nf sessions (18 received amygdala rtfMRI-nf, 16 received control parietal rtfMRI-nf). One-week prior-to and following training participants also completed a resting-state fMRI scan. A GLM-based functional connectivity analysis was applied using a seed ROI in the left amygdala. We compared amygdala functional connectivity changes while recalling positive AMs from the baseline run to the final transfer run during rtfMRI-nf training, as well during rest from the baseline to the one-week follow-up visit. Finally, we assessed the correlation between change in depression scores and change in amygdala connectivity, as well as correlations between amygdala regulation success and connectivity changes. Results Following training, amygdala connectivity during positive AM recall increased with widespread regions in the frontal and limbic network. During rest, amygdala connectivity increased following training within the fronto-temporal-limbic network. During both task and resting-state analyses, amygdala-temporal pole connectivity decreased. We identified increased amygdala-precuneus and amygdala-inferior frontal gyrus connectivity during positive memory recall and increased amygdala-precuneus and amygdala-thalamus connectivity during rest as functional connectivity changes that explained significant variance in symptom improvement. Amygdala-precuneus connectivity changes also explain a significant amount of variance in neurofeedback regulation success. Conclusions Neurofeedback training to increase amygdala hemodynamic activity during positive AM recall increased amygdala connectivity with regions involved in self-referential, salience, and reward processing. Results suggest future targets for neurofeedback interventions, particularly interventions involving the precuneus.<br />Highlights • Changes in amygdala functional connectivity following neurofeedback were examined. • Amygdala rtfMRI-nf training alters functional connectivity with prefrontal regions. • Increased amygdala-precuneus connectivity may underlie clinical improvements.
- Subjects :
- Male
Precuneus
Audiology
lcsh:RC346-429
Resting-state
Functional connectivity
0302 clinical medicine
Image Processing, Computer-Assisted
Depression
05 social sciences
Regular Article
Neurofeedback
Middle Aged
Amygdala
Magnetic Resonance Imaging
Positive memory recall
medicine.anatomical_structure
Neurology
Major depressive disorder
lcsh:R858-859.7
Female
Psychology
psychological phenomena and processes
Adult
medicine.medical_specialty
Memory, Episodic
Rest
Cognitive Neuroscience
lcsh:Computer applications to medicine. Medical informatics
050105 experimental psychology
Young Adult
03 medical and health sciences
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Psychiatric Status Rating Scales
Analysis of Variance
Depressive Disorder, Major
Resting state fMRI
Recall
Autobiographical memory
Frontal gyrus
medicine.disease
Oxygen
nervous system
Mental Recall
Neurology (clinical)
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 22131582
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- NeuroImage: Clinical
- Accession number :
- edsair.doi.dedup.....9f4ccf6e1879a1adcdfd439befc95ddd