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Antihypertensive and metabolic effects of single and combined atenolol regimens
- Source :
- Journal of clinical pharmacology. 32(1)
- Publication Year :
- 1992
-
Abstract
- The antihypertensive and metabolic effects of placebo (PL), a fixed combination of hydrochlorothiazide (25 mg) and triamterene (50 mg) (HCTZ/TRI), atenolol (25 mg) (Ate-25), atenolol (50 mg) (Ate-50) and their combination with HCTZ/TRI given once daily, were tested on 256 patients with mild-to-moderate essential hypertension. After 3 weeks of PL monotherapy, 43 patients were randomized to PL (group 1), 41 patients to HCTZ/TRI (group 2), 44 patients to Ate-25 (group 3), 42 patients to Ate-50 (group 4), 43 patients to Ate-25/HCTZ/TRI (group 5), and 43 patients to Ate-50/HCTZ/TRI (group 6) in a double-blind parallel design study and were followed for 4 weeks. At the end of week 7, those patients who were randomized to groups 5 and 6 were allowed to continue for an additional 12 weeks, if their arterial pressure was satisfactorily controlled. Complete blood counts, blood chemistries, urinalyses, and electrocardiograms were done initially and during the study. Monotherapy with HCTZ/TRI, Ate-25, and Ate-50 had significant and equal antihypertensive effects compared with placebo. (P
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Urology
Blood Pressure
Pharmacology
Placebo
Essential hypertension
Drug Administration Schedule
chemistry.chemical_compound
Hydrochlorothiazide
Double-Blind Method
Heart Rate
medicine
Humans
Pharmacology (medical)
Triamterene
Chemotherapy
business.industry
Middle Aged
medicine.disease
Atenolol
Drug Combinations
Blood pressure
chemistry
Hypertension
Uric acid
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00912700
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....9f4c012ad326fd289f16bd127d75c895