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Effects of radioprotective compounds and anti-inflammatory agents on the acute toxicity of trichothecenes
- Source :
- Toxicology Letters. 40:165-174
- Publication Year :
- 1988
- Publisher :
- Elsevier BV, 1988.
-
Abstract
- Antidotic effects of radioprotective and anti-inflammatory drugs against the acute toxicity of T-2 toxin and fusarenon-X, the trichothecene mycotoxins of Fusarium species, were examined in mice and rats with two toxicological parameters, the lethal toxicity and the increment of intestinal fluid volume. The s.c. and i.v. LD50 values of T-2 in male 6-week-old mice were 2.1 and 3.8 mg/kg, respectively, and the s.c. LD50 in 4-week-old mice was 1.6 mg/kg. Pretreatment of mice with steroidal anti-inflammatory agents such as prednisolone and hydrocortisone resulted in a marked reduction in the lethal toxicity of T-2 toxin. However, pretreatment of mice with several radioprotective agents exhibited neither a prolongation of survival time nor a decrease in lethal toxicity in the mice. Enteropooling assay revealed that the steroidal anti-inflammatory drugs also depressed the trichothecene-induced increment of intestinal fluid volume in rats, while no significant effects were observed with non-steroidal inhibitors of the arachidonate cascade. In rats given fusarenon-X, the content of cyclic AMP in the mucosa of ileum was dose- and time-dependently increased, but its maximal increment was only 1.5-fold of the control value. These findings indicate an involvement of the action site of steroidal anti-inflammatory drugs in the development of acute toxicity of trichothecenes in rodents.
- Subjects :
- Male
Hydrocortisone
Radioprotective Agent
medicine.drug_class
Prednisolone
Trichothecene
Anti-Inflammatory Agents
Radiation-Protective Agents
Pharmacology
Toxicology
Median lethal dose
Dinoprostone
Anti-inflammatory
Lethal Dose 50
Mice
chemistry.chemical_compound
Intestinal mucosa
Ileum
Cyclic AMP
medicine
Animals
Intestinal Mucosa
Binding Sites
Dose-Response Relationship, Drug
Chemistry
Prostaglandins E
Rats, Inbred Strains
General Medicine
Acute toxicity
Rats
Intestines
Nordihydroguaiaretic acid
T-2 Toxin
Toxicity
Colchicine
Trichothecenes
Sesquiterpenes
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....9f486d07e9f762c74015c9e6d87fff2f