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Mouse models of sarcopenia: classification and evaluation
- Source :
- Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 538-554 (2021), Journal of Cachexia, Sarcopenia and Muscle
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an increased possibility of adverse consequences such as falls, fractures, physical disabilities and death, and its risk increases with age. With the deepening of the understanding of sarcopenia, the disease has become a major clinical disease of the elderly and a key challenge of healthy ageing. However, the exact molecular mechanism of this disease is still unclear, and the selection of treatment strategies and the evaluation of its effect are not the same. Most importantly, the early symptoms of this disease are not obvious and are easy to ignore. In addition, the clinical manifestations of each patient are not exactly the same, which makes it difficult to effectively study the progression of sarcopenia. Therefore, it is necessary to develop and use animal models to understand the pathophysiology of sarcopenia and develop therapeutic strategies. This paper reviews the mouse models that can be used in the study of sarcopenia, including ageing models, genetically engineered models, hindlimb suspension models, chemical induction models, denervation models, and immobilization models; analyses their advantages and disadvantages and application scope; and finally summarizes the evaluation of sarcopenia in mouse models.
- Subjects :
- 0301 basic medicine
Aging
Sarcopenia
Hindlimb unloading
Reviews
Disease
Review
Diseases of the musculoskeletal system
Bioinformatics
Chemical induction
Mouse model
Healthy Aging
03 medical and health sciences
Mice
0302 clinical medicine
Physiology (medical)
Medicine
Animals
Humans
Orthopedics and Sports Medicine
Muscle, Skeletal
Aged
Skeletal muscle disease
business.industry
Genetically engineered
QM1-695
Clinical disease
medicine.disease
musculoskeletal system
Ageing
030104 developmental biology
Hindlimb Suspension
RC925-935
030220 oncology & carcinogenesis
Genetic engineering
Human anatomy
Molecular mechanism
Treatment strategy
Healthy ageing
business
human activities
Subjects
Details
- Language :
- English
- ISSN :
- 21905991 and 21906009
- Volume :
- 12
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Cachexia, Sarcopenia and Muscle
- Accession number :
- edsair.doi.dedup.....9f4110d6df2562ef077ae564e1d6b256